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Soy phytoestrogens modify DNA methylation of GSTP1, RASSF1A, EPH2 and BRCA1 promoter in prostate cancer cells.
Epigenetic modifications of DNA, such as the promoter CpG island demethylation of tumor suppressor genes, might be related to the protective effect of soy on prostate cancer. Expand
Association between genetic polymorphisms and ovarian cancer risk.
BACKGROUND The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in theExpand
DNA repair gene ERCC2, XPC, XRCC1, XRCC3 polymorphisms and associations with bladder cancer risk in a French cohort.
The Gln allele of the XPC 939 polymorphism was found to be associated with an increase in bladder cancer risk, which is seen as a polygenic disease. Expand
Resveratrol and breast cancer chemoprevention: molecular mechanisms.
Resveratrol has anti-oxidant and anti-inflammatory properties, and may induce apoptosis as well as modulate cell cycle and estrogen receptor function in breast cancer cell lines. Expand
Genetic polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 genes and association with bladder cancer risk in a French cohort.
Investigation of the association between functional polymorphisms in CYP1A1, CYp1B1, COMT, GSTP1 and NAT2 genes and BC risk consistent with previous literature among Caucasian populations found no statistically significant effects on BC risk. Expand
BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls.
Analysis of site-specific DNA methylation in PBCs by QAMA provides quantitativeDNA methylation values that may serve as important prognostic indicators. Expand
Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences.
Characteristics of breast cancer in patients from Lebanon, Tunisia and Morocco were more aggressive and patients were 10 years younger at diagnosis, and an up-regulation of cytokeratins KRT8 and KRT18 may indicate a luminal B subtype in "South" (Lebanon) tumors while "North" (France) tumors may more frequently be luminal A type. Expand
DNA repair genes implicated in triple negative familial non-BRCA1/2 breast cancer predisposition.
Taking into consideration a specific subtype of tumour has revealed susceptibility genes, most of them in the homologous recombination DNA repair pathway, which may provide new possibilities for targeted therapies, along with better screening and care of patients. Expand
Genistein and daidzein act on a panel of genes implicated in cell cycle and angiogenesis by polymerase chain reaction arrays in human prostate cancer cell lines.
Modulations of cyclin-dependent kinase-related pathway genes, DNA damage-signaling pathway and a down-regulation of EGF and IGF are demonstrated in men diagnosed with prostate cancer by using different prostate cancer cell lines. Expand
DNA methylation and soy phytoestrogens: quantitative study in DU-145 and PC-3 human prostate cancer cell lines.
This study showed that the soy phytoestrogens, genistein and daidzein, induce a decrease of methylation of BRCA1, GSTP1 and EPHB2 promoters, therefore, soy phYtoestrogen may have a protective effect on prostate cancer. Expand