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Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle.
Phosphodiesterase isozymes were isolated by diethylaminoethyl ether (DEAE) column chromatography from cardiac muscle (canine, guinea pig), vascular (canine and guinea pig aortic) and airway (canineExpand
  • 110
  • 3
Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase
Multiple molecular forms of cyclic nucleotide phosphodiesterase have been identified previously in several tissues and cell types using a variety of different isolation methods. In the present study,Expand
  • 239
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Inhibition by SQ 20881 of vasopressor response to angiotensin I in conscious animals.
Abstract A synthetic nonapeptide structurally identical to one of the compounds found in the venom of Bothrops jararaca was studied in unanesthetized rats and dogs. The nonapeptide, administered byExpand
  • 41
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Phosphodiesterase isozyme inhibition, activation of the cAMP system, and positive inotropy mediated by milrinone in isolated guinea pig cardiac muscle.
The purpose of the present study was to examine the interrelationships among phosphodiesterase (PDE) isozyme inhibition, cAMP formation, activation of cAMP-dependent protein kinase (cAPK), andExpand
  • 53
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Adenosine receptors mediating cardiac depression.
Several adenosine analogs were evaluated for their effects on rate and contractility in guinea pig isolated atria. Among adenosine agonists, (-)-N-(1-methyl-2-phenylethyl) adenosineExpand
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Pharmacology of nadolol (SQ 11725), a beta-adrenergic antagonist lacking direct myocardial depression.
SQ 11725 was approximately 1/3 as potent as propranolol in blocking the stimulant effects of isoproterenol in vitro, but was 2-4 times more potent than propranolol in blocking the diastolicExpand
  • 102
Modulation of cAMP: Mechanism for Positive Inotropic Action
  • D. B. Evans
  • Chemistry, Medicine
  • Journal of cardiovascular pharmacology
  • 1986
Modulation of intracellular cAMP in cardiac cells results in a positive inotropic effect. This effect is achieved by increasing intracellular cAMP. via a variety of ways, which leads to theExpand
  • 47
Overview of cardiovascular physiologic and pharmacologic aspects of selective phosphodiesterase peak III inhibitors.
  • D. B. Evans
  • Medicine
  • The American journal of cardiology
  • 3 January 1989
In recent years several agents have been developed as selective inhibitors of the low Michaelis constant cyclic adenosine monophosphate (cAMP) phosphodiesterase (peak III), a fraction of the cyclicExpand
  • 39
Studies aimed at elucidating the mechanism of action of CI-914, a new cardiotonic agent.
CI-914 is a novel positive inotropic agent whose cardiotonic activity is not due to inhibition of Na+, K+-ATPase or to stimulation of cardiac beta-receptors. CI-914 also has no direct effect onExpand
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