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Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens
The development of liver tumours, in animals fed five structually diverse hypolipidaemic compounds, supports the hypothesis that potent hepatic peroxisome proliferators as a class are carcinogenic. Expand
Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicyclic acid in sewage water effluent.
Abstract Chlorophenoxyisobutyrate (CPIB) and salicylic acid, the metabolites of clofibrate and aspirin, were quantitated by gas chromatography-mass spectrometry in the effluent of a sewage disposalExpand
Computer-controlled Infusion of Intravenous Dexmedetomidine Hydrochloride in Adult Human Volunteers
Pharmacokinetics of dexmedetomidine are best described by a three-compartment model, and the addition of age, weight, lean body mass, and body surface area as covariates of the pharmacokinetic parameters did not improve the predictive value of the model. Expand
The Effects of Urine pH and Plasma Protein Binding on the Renal Clearance of Disopyramide
Renal clearance of disopyramide was found to vary with time, which is partly the result of a concentration dependent change in plasma protein binding, and the unbound fraction of drug in plasma varied from 0.32 to 0.72 between 0.4 to 4μg/ml concentration. Expand
Correlation between plasma diphenhydramine level and sedative and antihistamine effects.
There was a positive correlation between plasma diphenhydramine level and sedative and antihistamine effects, but wide variation in the extent and rate of change of these effects were observed between the subject. Expand
Clinical Pharmacokinetics of Methotrexate
SummaryThe absorption of methotrexate following intramuscular injection and oral administration of small doses (>30mg/m2) is rapid and complete, whereas with oral doses in excess of 80mg/m2Expand
Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator, [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14, 643), in rat and mouse liver.
The observation that nafenopin and Wy-14,643, 2 structurally unrelated hypolipidemic agents, induce “primary” liver cell proliferation and hepatocellular carcinomas prompts a concern over the potential carcinogenicity of hepatic peroxisome proliferators as a class. Expand
Pharmacokinetics of methotrexate
It is demonstrated that intravenous administration of 30 mg 3H‐Mtx/M2 to patients with a variety of malignancies is followed by a triphasic disappearance of the drug from plasma with a half‐life of 0.75 ± 0.11%, and ingestion of meals, but not changes in pH, were associated with an increased rate of excretion, suggesting an enterohepatic circulation. Expand
Drugs and Drug Metabolites as Environmental Contaminants: Detection of Chlorophenoxyisobutyrate and Salicylic Acid by GC-MS
The annual consumption of many drugs in the United States is measured in thousands of kilograms and many of these drugs pass through the body unchanged or are eliminated as biologically activeExpand
Reversal experiments demonstrate that liver cells revert to normal between 2 and 3 weeks after withdrawal of CPIB and that one of the mechanisms for removal of excess microbodies is their incorporation into structures indistinguishable from lysosomes. Expand