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European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia
Owing to increasing resistance and the limited arsenal of new antibiotics, especially against Gram-negative pathogens, carefully designed antibiotic regimens are obligatory for febrile neutropenic… Expand
Functional STAT3 deficiency compromises the generation of human T follicular helper cells.
T follicular helper (Tfh) cells are critical for providing the necessary signals to induce differentiation of B cells into memory and Ab-secreting cells. Accordingly, it is important to identify the… Expand
Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients.
OBJECTIVES A knowledge of current epidemiology and resistance patterns is crucial to the choice of empirical treatment for bacteraemias in haematology and cancer patients. METHODS A literature… Expand
Targeted therapy against multi-resistant bacteria in leukemic and hematopoietic stem cell transplant recipients: guidelines of the 4th European Conference on Infections in Leukemia (ECIL-4, 2011)
The detection of multi-resistant bacterial pathogens, particularly those to carbapenemases, in leukemic and stem cell transplant patients forces the use of old or non-conventional agents as the only… Expand
Mutation D30N Is Not Preferentially Selected by Human Immunodeficiency Virus Type 1 Subtype C in the Development of Resistance to Nelfinavir
- Z. Grossman, E. Paxinos, +10 authors J. Schapiro
- Biology, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 June 2004
ABSTRACT Differences in baseline polymorphisms between subtypes may result in development of diverse mutational pathways during antiretroviral treatment. We compared drug resistance in patients with… Expand
Genetic variation at NNRTI resistance-associated positions in patients infected with HIV-1 subtype C
Objective: Genetic differences between subtypes of HIV-1, even when not associated with key resistance mutations, are known to affect baseline susceptibility to specific antiretroviral drugs and… Expand
Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells
- E. Deenick, D. T. Avery, +28 authors S. Tangye
- Medicine, Biology
- The Journal of experimental medicine
- 18 November 2013
Memory B cells, unlike naive B cells, require a reduced level of STAT3 activation to differentiate into antibody-secreting plasmablasts in response to IL-10 and IL-21; however, this process requires… Expand
A partial form of recessive STAT1 deficiency in humans.
- A. Chapgier, Xiao-Fei Kong, +12 authors Jean-Laurent Casanova
- Biology, Medicine
- The Journal of clinical investigation
- 1 June 2009
Complete STAT1 deficiency is an autosomal recessive primary immunodeficiency caused by null mutations that abolish STAT1-dependent cellular responses to both IFN-alpha/beta and IFN-gamma. Affected… Expand
Complicated community acquired pneumonia in childhood: Different types, clinical course, and outcome
The incidence of pediatric community acquired complicated pneumonia (PCACP) is increasing. Questions addressed: Are different types of PCACP one disease? How do different treatment protocols affect… Expand
Macrolide resistance in Mycoplasma pneumoniae, Israel, 2010.
- D. Averbuch, C. Hidalgo-Grass, A. Moses, D. Engelhard, R. Nir-Paz
- Emerging infectious diseases
Macrolide resistance in Mycoplasma pneumoniae is often found in Asia but is rare elsewhere. We report the emergence of macrolide-resistant M. pneumoniae in Israel and the in vivo evolution of such… Expand