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Biological effects of essential oils--a review.
Reassembly of shattered chromosomes in Deinococcus radiodurans
TLDR
This work describes the relevant two-stage DNA repair process, which involves a previously unknown molecular mechanism for fragment reassembly called ‘extended synthesis-dependent strand annealing’ (ESDSA), followed and completed by crossovers.
Dose-effect relationships and estimation of the carcinogenic effects of low doses of ionizing radiation
TLDR
Recent radiobiological data undermine the validity of estimations based on LNT in the range of doses lower than a few dozen mSv which leads to the questioning of the hypotheses on which LNT is implicitly based.
Characterization of homologous recombination induced by replication inhibition in mammalian cells
TLDR
It is proposed that replication inhibition produces DSBs, which are first processed by the NHEJ; then, following DSB accumulation, RAD51 recombination can act.
The debate on the use of linear no threshold for assessing the effects of low doses.
TLDR
The epidemiological data and the experimental data challenge the validity of the LNT hypothesis for assessing the carcinogenic effect of low doses, but do not allow its exclusion.
Recent reports on the effect of low doses of ionizing radiation and its dose–effect relationship
TLDR
The conclusion of the French Report is that the linear no-threshold relationship (LNT) may greatly overestimate the carcinogenic effect of low doses and even more that of very low doses, such as those delivered during X-ray examinations.
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.
TLDR
It is shown here that ICL activates the assembly of the RMN proteins into subnuclear foci, and that their formation proceeds independently of ICL incision, a step mainly dependent on XP-F/ERCC1 heterodimer activity.
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