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Physicochemical Principles of Pharmacy
This book brings together the importance of the physicochemical principles in terms of formulation and quality control, and the final goal of pharmacy assistance, which is to ensure the delivery of the drug to its site of action and promote a safe and desired response. Expand
The influence of surface modification on the cytotoxicity of PAMAM dendrimers.
A marked decrease in the cytot toxicity of cationic PAMAM dendrimers was noted when the surface was modified, with the addition of six lauroyl or four PEG chains being particularly effective in decreasing cytotoxicity. Expand
Surfactant Systems: Their chemistry, pharmacy and biology
1. Surface activity.- 1.1 Amphipathic molecules.- 1.2 Surface activity in aqueous solution.- 1.3 Adsorption at liquid surfaces.- 1.4 Adsorption at solid surfaces.- 1.5 The wettability of solidExpand
An in vivo investigation into the suitability of pH dependent polymers for colonic targeting
Abstract The effect of a pH-dependent polymer coating, Eudragit S, on its ability to protect a model drug and control its release from rapidly disintegrating tablets has been examined in vitro.Expand
Dendrimer-drug interactions.
The application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability and the use of the complexes as vehicles for the controlled release of drugs and drug targeting is discussed. Expand
Engineering of Dendrimer Surfaces to Enhance Transepithelial Transport and Reduce Cytotoxicity
The properties of dendrimers may be significantly modified by surface engineering and can cross epithelial monolayers by paracellular and transcellular pathways. Expand
Polyamidoamine Starburst dendrimers as solubility enhancers.
The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS) and the results suggest that it involves an electrostatic interaction between the carboxyl group of the ib uprofen molecule and the amine groups of the d endrimer molecule. Expand
Thermally reversible xyloglucan gels as vehicles for rectal drug delivery.
The results of this study suggest the potential of the enzyme-degraded xyloglucan gels as vehicles for rectal delivery of drugs. Expand
The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability.
The results suggest that dendrimer-drug prodrugs may be used to increase drug solubility and bypass drug efflux transporters, therefore increasing drug bioavailability. Expand
An evaluation of pectin as a carrier for drug targeting to the colon
In vitro experiments demonstrated that high methoxy pectin (pectin USP), when applied as a compression coat, proved capable of protecting a core tablet during conditions mimicking mouth-to-colon transit and was susceptible to enzymatic attack. Expand