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Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos
TLDR
The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation. Expand
CYP1A1, CYP19, and GSTM1 polymorphisms increase the risk of endometriosis.
TLDR
The data suggest that CYP19 VNTR (TTTA)(10) allele as well as the combined genotype CYP1A1 m1 polymorphism and GSTM1null deletion associate with the endometriosis phenotype, whereas the GSTT1 null deletion does not. Expand
The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival.
TLDR
It is suggested that HAX-1 may promote cell survival through modulation of SERCA2 protein levels and thus ER Ca(2+) stores. Expand
Dual role of junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes
TLDR
Understanding how calcium within the sarcoplasmic reticulum helps to regulate ryanodine receptor activity in normal hearts and also helps to understand why junctin is decreased in patients diagnosed with certain forms of heart failure. Expand
Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function.
TLDR
Findings suggest a possible link between the Ca(2+) handling by the sarcoplasmic reticulum and cell survival mediated by the PLN/HAX-1 interaction. Expand
Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.
TLDR
The data suggest that HRC may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart. Expand
Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer.
TLDR
RT-PCR analysis provided evidence that CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes are frequently deregulated in breast cancer and could be used as molecular biomarkers for better clinical management of such patients, with respect to chemotherapy. Expand
The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion.
TLDR
The 259-Pro allele seems to have beneficial influences during embryogenesis, conceivably through its positive effect on vitamin B(12) intracellular bioavailability, and warrant additional investigations addressing the question if vitamin B (12) supplementation in addition to folic acid supplementation may prevent spontaneous abortion in women planning a pregnancy. Expand
Muscle Lim Protein Interacts with Cofilin 2 and Regulates F-Actin Dynamics in Cardiac and Skeletal Muscle
TLDR
It is shown for the first time, using a range of biochemical and immunohistochemical methods, that MLP binds directly to CFL2 in human cardiac and skeletal muscles, with direct implications in actin cytoskeleton dynamics in regulating CFL2-dependent F-actin depolymerization. Expand
Low-penetrance genes are associated with increased susceptibility to endometriosis.
TLDR
The combination of CYP1A1 m1 polymorphism and GSTM1 null deletion is closely associated with penetration of the endometriosis phenotype, whereas GSTT1null deletion may add to the penetration of this trait. Expand
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