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Orai proteins interact with TRPC channels and confer responsiveness to store depletion
The TRPC (C-type transient receptor potential) class of ion channels has been hypothesized to participate in store-operated Ca2+ entry (SOCE). Recently, however, STIM1 and Orai1 proteins have beenExpand
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Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels
Receptor-operated Ca2+ entry (ROCE) and store-operated Ca2+ entry (SOCE) into cells are functions performed by all higher eukaryotic cells, and their impairment is life-threatening. The mainExpand
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Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization.
Two classes of calcium channels were activated by membrane depolarization in cell-free membrane patches from GH3 cells, an electrically excitable cell line derived from a mammalian pituitary tumor.Expand
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Rac and Rho Mediate Opposing Hormonal Regulation of the Ether-A-Go-Go-Related Potassium Channel
BACKGROUND Previous studies of ion channel regulation by G proteins have focused on the larger, heterotrimeric GTPases, which are activated by heptahelical membrane receptors. In contrast, studies ofExpand
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Structure of a signal transduction regulator, RACK1, from Arabidopsis thaliana
The receptor for activated C‐kinase 1 (RACK1) is a highly conserved WD40 repeat scaffold protein found in a wide range of eukaryotic species from Chlamydymonas to plants and humans. In tissues ofExpand
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Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone.
Many nuclear hormones have physiological effects that are too rapid to be explained by changes in gene expression and are often attributed to unidentified or novel G protein-coupled receptors.Expand
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Stimulation of Kv1.3 Potassium Channels by Death Receptors during Apoptosis in Jurkat T Lymphocytes*
The loss of intracellular potassium is a pivotal step in the induction of apoptosis but the mechanisms underlying this response are poorly understood. Here we report caspase-dependent stimulation ofExpand
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Conditional and Unconditional Inhibition of Calcium-activated Potassium Channels by Reversible Protein Phosphorylation*
Large conductance, calcium-activated potassium channels (BKCa or maxi-K) are important determinants of membrane excitability in many cell types. We used patch clamp techniques to study theExpand
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Stable Activation of Single Ca2+ Release-activated Ca2+ Channels in Divalent Cation-free Solutions*
The regulation of store-operated, calcium-selective channels in the plasma membrane of rat basophilic leukemia cells (RBL-2H3 m1), an immortalized mucosal mast cell line, was studied at theExpand
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Calcium-dependent inactivation of the dihydropyridine-sensitive calcium channels in GH3 cells
The inactivation of calcium channels in mammalian pituitary tumor cells (GH3) was studied with patch electrodes under voltage clamp in cell- free membrane patches and in dialyzed cells. The calciumExpand
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