• Publications
  • Influence
Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.
This study determined whether retinal degeneration during diabetes includes retinal neural cell apoptosis. Image analysis of retinal sections from streptozotocin (STZ) diabetic rats after 7.5 monthsExpand
  • 1,013
  • 42
  • PDF
The Ins2Akita mouse as a model of early retinal complications in diabetes.
PURPOSE This study tested the Ins2(Akita) mouse as an animal model of retinal complications in diabetes. The Ins2(Akita) mutation results in a single amino acid substitution in the insulin 2 geneExpand
  • 421
  • 29
  • PDF
Diabetic retinopathy.
O ver 135 million individuals are afflicted with diabetes across the world. In the U.S., diabetes affects over 18.2 million people (or 6.3% of the total population) and 800,000 new cases of type 2Expand
  • 241
  • 21
  • PDF
Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1
Vascular endothelial growth factor (VEGF) may have a physiologic role in regulating vessel permeability and contributes to the pathophysiology of diabetic retinopathy as well as tumor development. WeExpand
  • 516
  • 20
  • PDF
Regulation of tight junctions and loss of barrier function in pathophysiology.
The mechanism by which epithelial and endothelial cells interact to form polarized tissue is of fundamental importance to multicellular organisms. Dysregulation of these barriers occurs in a varietyExpand
  • 479
  • 20
Diabetic Retinopathy
Diabetic retinopathy remains a frightening prospect to patients and frustrates physicians. Destruction of damaged retina by photocoagulation remains the primary treatment nearly 50 years after itsExpand
  • 516
  • 18
  • PDF
Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State
Blood-retinal barrier (BRB) breakdown is a hallmark of diabetic retinopathy, but the molecular changes that cause this pathology are unclear. Occludin is a transmembrane component of interendothelialExpand
  • 541
  • 16
TNF-α Signals Through PKCζ/NF-κB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability
OBJECTIVE Tumor necrosis factor-α (TNF-α) and interleukin-1 beta (IL-1β) are elevated in the vitreous of diabetic patients and in retinas of diabetic rats associated with increased retinal vascularExpand
  • 254
  • 12
  • PDF
Diabetic retinopathy: more than meets the eye.
Retinal microvascular dysfunction in diabetes is a major component of diabetic retinopathy. This review highlights recent observations regarding the cellular anatomy that contributes to theExpand
  • 501
  • 11
Insulin Rescues Retinal Neurons from Apoptosis by a Phosphatidylinositol 3-Kinase/Akt-mediated Mechanism That Reduces the Activation of Caspase-3*
The ability of insulin to protect neurons from apoptosis was examined in differentiated R28 cells, a neural cell line derived from the neonatal rat retina. Apoptosis was induced by serum deprivation,Expand
  • 279
  • 10