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A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane.
TLDR
Results suggest that band 3 forms the core of a macrocomplex of integral and peripheral RBC membrane proteins that may function as an integrated CO(2)/O(2) gas exchange unit (metabolon) in the erythrocyte.
Monoclonal antibodies inhibit prion replication and delay the development of prion disease
TLDR
Investigating in a murine scrapie model whether anti-PrP monoclonal antibodies show similar inhibitory effects on prion replication in vivo found that peripheral PrPSc levels and prion infectivity were markedly reduced, even when the antibodies were first administered at the point of near maximal accumulation of PrP Sc in the spleen.
Mollison's Blood Transfusion in Clinical Medicine
TLDR
The transfusion of blood, blood components and plasma alternatives in oligaemia, and some unfavourable effects of transfusion, are described.
The relationship between blood groups and disease.
TLDR
Investigation of the migration patterns of early humans from Africa to populate the rest of the world obtained through the use of Y chromosome and mtDNA markers suggests surviving malaria is the most significant selective force affecting the expression of blood groups.
Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype.
TLDR
People with the In(Lu) phenotype have no reported pathology, indicating that one functional EKLF allele is sufficient to sustain human erythropoiesis and the first demonstration of a blood group phenotype resulting from mutations in a transcription factor is demonstrated.
CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin.
TLDR
It is concluded that CD151 is essential for the proper assembly of the glomerular and tubular basement membrane in kidney, has functional significance in the skin, is probably a component of the inner ear, and could play a role in erythropoiesis.
cDNA cloning of a 30 kDa erythrocyte membrane protein associated with Rh (Rhesus)-blood-group-antigen expression.
TLDR
The N-terminal 54 amino acid residues of the 30 kDa Rh D polypeptide are determined and sequence data and the polymerase chain reaction (PCR) on human reticulocyte cDNA and genomic DNA are used to clone two types of PCR product of identical size.
Identification of the Membrane Attachment Sites for Protein 4.1 in the Human Erythrocyte (*)
TLDR
The results suggest that the most significant interactions between protein 4.1 and the membrane are those involving p55, while those involving GPC/D and band 3 are 100-fold lower (μM).
Red cell genotyping and the future of pretransfusion testing.
TLDR
Routine use of DNA-based extended phenotyping to provide optimally matched donations for patients with preexisting antibodies or patients with a known predisposition to alloimmunization, such as those with sickle cell disease, is widely used.
An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells
TLDR
It is demonstrated a feasible approach to the manufacture of red cells for clinical use from in vitro culture, immortalizing early adult erythroblasts generating a stable line, which provides a continuous supply ofred cells.
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