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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
IMPORTANCE Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology,… Expand
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016
Objective: To provide an update to “Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012.” Design: A consensus committee of 55 international experts representing 25… Expand
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
ObjectiveTo provide an update to “Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012”.DesignA consensus committee of 55 international experts representing 25… Expand
Clinical practice guideline on diagnosis and treatment of hyponatraemia.
- G. Spasovski, R. Vanholder, +14 authors E. Nagler
- European journal of endocrinology
- 1 April 2014
Hyponatraemia, defined as a serum sodium concentration <135 mmol/l, is the most common disorder of body fluid and electrolyte balance encountered in clinical practice. It can lead to a wide spectrum… Expand
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of…
Objective:To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients. Participants:A multidisciplinary, multispecialty task… Expand
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock.
CONTEXT Septic shock may be associated with relative adrenal insufficiency. Thus, a replacement therapy of low doses of corticosteroids has been proposed to treat septic shock. OBJECTIVE To assess… Expand
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock 2012
Objective:To provide an update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008. Design:A consensus committee of 68 international… Expand
Hydrocortisone therapy for patients with septic shock.
- C. Sprung, D. Annane, +12 authors J. Briegel
- The New England journal of medicine
- 10 January 2008
BACKGROUND Hydrocortisone is widely used in patients with septic shock even though a survival benefit has been reported only in patients who remained hypotensive after fluid and vasopressor… Expand
A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study
PurposeAn optimal target for glucose control in ICU patients remains unclear. This prospective randomized controlled trial compared the effects on ICU mortality of intensive insulin therapy (IIT)… Expand
Current epidemiology of septic shock: the CUB-Réa Network.
- D. Annane, P. Aegerter, M. Jars-Guincestre, B. Guidet
- American journal of respiratory and critical care…
- 15 July 2003
To update the epidemiology of septic shock we analyzed clinical, microbiologic, and outcome variables from 100,554 intensive care unit admissions on the Collège des Utilisateurs de Bases de données… Expand