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Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
- R. Tice, E. Agurell, +7 authors Y. Sasaki
- Biology, Medicine
- Environmental and molecular mutagenesis
Atthe International Workshop on Genotoxicity Test Procedures (IWGTP) held in Washington, DC, March 25–26, 1999, an expert panel met to develop guidelines for the use of the single‐cell gel… Expand
IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety.
The purpose of these guidelines is to provide concise guidance on the planning, performing and interpretation of studies to monitor groups or individuals exposed to genotoxic agents. Most human… Expand
The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay.
The effects of antioxidants and various other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes have been investigated using the COMET assay. Hydrogen peroxide (H2O2) and… Expand
Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)
The wide scale use of Zinc oxide (ZnO) nanoparticles in the world consumer market makes human beings more prone to the exposure to ZnO nanoparticles and its adverse effects. The liver, which is the… Expand
Function of hexameric RNA in packaging of bacteriophage phi 29 DNA in vitro.
A cyclic hexamer of the 120-base prohead RNA (pRNA) is needed for efficient in vitro packaging of the B. subtilis bacteriophage phi 29 genome. This capacity of pRNA to form higher multimers by… Expand
Comet assay responses as indicators of carcinogen exposure.
Over 200 agents/factors have been examined in the single cell gel electrophoresis assay, more commonly known as the Comet assay, performed either in vitro or in vivo in a variety of species.… Expand
Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme.
Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for… Expand
Oestrogenic compounds and oxidative stress (in human sperm and lymphocytes in the Comet assay).
- D. Anderson, T. Schmid, A. Baumgartner, Eduardo Cemeli-Carratala, M. Brinkworth, J. M. Wood
- Chemistry, Medicine
- Mutation research
- 1 November 2003
Reactive oxygen species (ROS) are produced by a wide variety of chemicals and physiological processes in which enzymes catalyse the transfer of electrons from a substrate to molecular oxygen. The… Expand
Zinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytes.
- V. Sharma, Suman K. Singh, D. Anderson, D. Tobin, A. Dhawan
- Materials Science, Medicine
- Journal of nanoscience and nanotechnology
- 1 May 2011
Zinc oxide (ZnO) nanoparticles are widely used in cosmetics and sunscreens. Human epidermal keratinocytes may serve as the first portal of entry for these nanoparticles either directly through… Expand
Modulating effects of flavonoids on food mutagens in human blood and sperm samples in the comet assay.
- D. Anderson, N. Başaran, M. Dobrzyńska, A. Başaran, T. Yu
- Chemistry, Medicine
- Teratogenesis, carcinogenesis, and mutagenesis
The flavonoids silymarin, myricetin, quercetin, kaempferol, rutin, and kaempferol-3-rutinoside have been examined in combination with the food mutagens 3-amino-1-methyl-5H-pyrido (4,3-b)indole (Trp)… Expand