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Triterpene glycosides from sea cucucmbers (holothurioidea, echinodermata). Biological activities and functions
Anticancer Activity of Sea Cucumber Triterpene Glycosides
- D. Aminin, E. Menchinskaya, Evgeny A. Pisliagin, A. Silchenko, S. Avilov, V. Kalinin
- Biology, ChemistryMarine drugs
- 1 March 2015
Administration of solutions of some sea cucumber triterpene glycosides significantly reduces both tumor burden and metastasis and has the potential to be used as P-gp mediated MDR reversal agents in combined therapy with standard cytostatics.
Immunomodulatory properties of frondoside A, a major triterpene glycoside from the North Atlantic commercially harvested sea cucumber Cucumaria frondosa.
Frondoside A is an immunostimulant of cell-based immunity including phagocytosis without a significant effect on amplification of humoral immune activity or adjuvant properties and may provide curative and/or preventive treatment options against diseases wherein a depleted immune status contributes to the pathological processes.
Antitumor activity of the immunomodulatory lead Cumaside.
The rolB Gene Suppresses Reactive Oxygen Species in Transformed Plant Cells through the Sustained Activation of Antioxidant Defense1[C][W][OA]
- V. Bulgakov, T. Gorpenchenko, Y. Zhuravlev
- Biology, Environmental SciencePlant Physiology
- 23 January 2012
Reduced levels of reactive oxygen species (ROS) are demonstrated in rolB-expressing Rubia cordifolia, Panax ginseng, and Arabidopsis (Arabidopsis thaliana) cells and it is concluded that, similar to pathogenic determinants in other pathogenic bacteria, rol B suppresses ROS and plays a role not only in cell differentiation but also in ROS metabolism.
The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer
- S. Dyshlovoy, E. Menchinskaya, G. von Amsberg
- Biology, MedicineInternational journal of cancer
- 15 May 2016
The results suggest that FrA is a promising new drug for the treatment of mCRPC, with high efficacy in human prostate cancer cells, while non‐malignant cells were less sensitive to it.
Immunomodulatory properties of Cumaside.
Inhibition of Tumor Cells Multidrug Resistance by Cucumarioside A2-2, Frondoside A and their Complexes with Cholesterol
In non-cytotoxic concentrations, frondoside A (1) from the sea cucumber Cucumaria okhotensis and cucumarioside A2-2 (2) from C. japonica, as well as their complexes with cholesterol block the…
Immunomodulatory Properties of Cucumariosides from the Edible Far-Eastern Holothurian Cucumaria japonica.
- D. Aminin, I. Agafonova, E. Berdyshev, E. Isachenko, S. Avilov, V. Stonik
- Chemistry, BiologyJournal of medicinal food
In vitro, an inhibitory rather than a stimulatory effect of cucumariosides on phagocytosis and release of tumor necrosis factor-alpha (TNF-alpha) was found, and possible mechanisms underlying immunomodulatory properties of triterpene glycosides from C. japonica are discussed.
Decreased ROS level and activation of antioxidant gene expression in Agrobacterium rhizogenes pRiA4-transformed calli of Rubia cordifolia
- Y. Shkryl, G. Veremeichik, V. Bulgakov, T. Gorpenchenko, D. Aminin, Y. Zhuravlev
- 3 August 2010
Results demonstrate that A.rhizogenes, like other plant pathogens, uses a strategy aimed at decreasing ROS levels in host cells through the general upregulation of its antioxidant genes.