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The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer
TLDR
The recent findings on the interplay among SIRT1, oxidative stress, and DNA repair machinery and its impact on normal and cancer cells are discussed.
Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells
BRAF inhibitor (BRAFi) therapy for melanoma patients harboring the V600E mutation is initially highly effective, but almost all patients relapse within a few months. Understanding the molecular
Abstract 4669: Targeting hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells
TLDR
An unprecedented mechanism of vemurafenib resistance by GLI1/GLI2 upregulation was demonstrated, shedding light on the development of Hh pathway inhibitors as a promising strategy for melanoma treatment and demonstrated that GLI 1/ GLI2 modulation could be a useful strategy to prevent drug resistance.
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