D. Alsteens

Publications120
h-index39
Citations4,803
Highly Influential Citations163
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Force probing surfaces of living cells to molecular resolution.
Biological processes rely on molecular interactions that can be directly measured using force spectroscopy techniques. Here we review how atomic force microscopy can be applied to force probe… Expand
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Force-induced formation and propagation of adhesion nanodomains in living fungal cells
Understanding how cell adhesion proteins form adhesion domains is a key challenge in cell biology. Here, we use single-molecule atomic force microscopy (AFM) to demonstrate the force-induced… Expand
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Detection, localization, and conformational analysis of single polysaccharide molecules on live bacteria.
The nanoscale exploration of microbes using atomic force microscopy (AFM) is an exciting, rapidly evolving research field. Here, we show that single-molecule force spectroscopy is a valuable tool for… Expand
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A Role for Amyloid in Cell Aggregation and Biofilm Formation
Cell adhesion molecules in Saccharomyces cerevisiae and Candida albicans contain amyloid-forming sequences that are highly conserved. We have now used site-specific mutagenesis and specific peptide… Expand
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Strengthening relationships: amyloids create adhesion nanodomains in yeasts.
Budding yeasts adhere to biotic or abiotic surfaces and aggregate to form biofilms, using wall-anchored glycoprotein adhesins. The process is paradoxical: adhesins often show weak binding to specific… Expand
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Structure, cell wall elasticity and polysaccharide properties of living yeast cells, as probed by AFM.
Although the chemical composition of yeast cell walls is known, the organization, assembly, and interactions of the various macromolecules remain poorly understood. Here, we used in situ atomic force… Expand
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Multiparametric imaging of biological systems by force-distance curve–based AFM
A current challenge in the life sciences is to understand how biological systems change their structural, biophysical and chemical properties to adjust functionality. Addressing this issue has been… Expand
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The yeast Wsc1 cell surface sensor behaves like a nanospring in vivo.
Here we report on in vivo measurement of the mechanical behavior of a cell surface sensor using single-molecule atomic force microscopy. We focus on the yeast wall stress component sensor Wsc1, a… Expand
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Imaging modes of atomic force microscopy for application in molecular and cell biology.
Atomic force microscopy (AFM) is a powerful, multifunctional imaging platform that allows biological samples, from single molecules to living cells, to be visualized and manipulated. Soon after the… Expand
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High-resolution cell surface dynamics of germinating Aspergillus fumigatus conidia.
We used real-time atomic force microscopy with a temperature-controlled stage (37 degrees C) to probe the structural and physicochemical dynamics of single Aspergillus fumigatus conidia during… Expand
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