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Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
The distribution volume ratio (DVR), which is a linear function of receptor availability, is widely used as a model parameter in imaging studies. The DVR corresponds to the ratio of the DV of aExpand
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Serial microPET measures of the metabolic reaction to a microdialysis probe implant
Despite the widespread use of chronic brain implants in experimental and clinical settings, the effects of these long-term procedures on brain metabolism and receptor expression remain largelyExpand
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A Strategy for Removing the Bias in the Graphical Analysis Method
The graphical analysis method, which transforms multiple time measurements of plasma and tissue uptake data into a linear plot, is a useful tool for rapidly obtaining information about the binding ofExpand
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Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors
Dopamine's role in inhibitory control is well recognized and its disruption may contribute to behavioral disorders of discontrol such as obesity. Expand
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Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain
Caffeine, the most widely consumed psychoactive substance in the world, is used to promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants and modafinil), caffeineExpand
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Brain monoamine oxidase A inhibition in cigarette smokers.
Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and becauseExpand
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Therapeutic doses of amphetamine or methylphenidate differentially increase synaptic and extracellular dopamine
Methylphenidate (MP) and amphetamine (AMP) are first‐line treatments for attention‐deficit hyperactivity disorder. Although both drugs have similar therapeutic potencies, the stimulatory effect ofExpand
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Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs
Reboxetine is a specific norepinephrine transporter (NET) inhibitor and has been marketed in several countries as a racemic mixture of the (R,R) and (S,S) enantiomers for the treatment of depression.Expand
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Acute Handling Stress Modulates Methylphenidate-induced Catecholamine Overflow in the Medial Prefrontal Cortex
Although stress is an extensively investigated phenomenon, the effects of specific stressors on the pharmacologic activity of routinely administered drugs are less well characterized. We designed theExpand
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Imaging dopamine release with Positron Emission Tomography (PET) and 11C-raclopride in freely moving animals
We investigated an imaging strategy that provides simultaneous measurements of radiotracer binding and behavior in awake, freely moving animals. Expand
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