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Human papillomavirus positive squamous cell carcinoma of the oropharynx
Epidemiologic evidence points to a connection between viral infection by the human papillomavirus (HPV) and a subgroup of squamous cell carcinoma of the oropharynx. To assess the impact of HPVExpand
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Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.
Hypoxia has long been recognized as detrimental to the successful treatment of malignant tumors with ionizing radiation. Because hypoxia-inducible factor (HIF)-1alpha plays an essential role inExpand
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The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants
Point mutations constitute a major mode of oncogenic activation of the Met receptor tyrosine kinase. Met is aberrantly activated in many types of human malignancies and its deregulated activity isExpand
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Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?
BackgroundHypoxia-inducible factor 1 alpha (hif-1α) furnishes tumor cells with the means of adapting to stress parameters like tumor hypoxia and promotes critical steps in tumor progression andExpand
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Neoadjuvant chemotherapy and extrapleural pneumonectomy of malignant pleural mesothelioma with or without hemithoracic radiotherapy (SAKK 17/04): a randomised, international, multicentre phase 2
BACKGROUND Postoperative hemithoracic radiotherapy has been used to treat malignant pleural mesothelioma, but it has not been assessed in a randomised trial. We assessed high-dose hemithoracicExpand
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The essential role of radiotherapy in the treatment of Merkel cell carcinoma: a study from the Rare Cancer Network.
PURPOSE To evaluate the role of postoperative radiotherapy (RT) in Merkel cell carcinoma (MCC). METHODS AND MATERIALS A retrospective multicenter study was performed in 180 patients with MCCExpand
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The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer
Chemokines are a superfamily of small chemotactic cytokines, which interact with their G‐protein‐coupled receptors. These interactions regulate multiple physiological functions, particularly tissueExpand
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Involvement of the hepatocyte growth factor/scatter factor receptor c–met and of Bcl–xL in the resistance of oropharyngeal cancer to ionizing radiation
The activation of cytoplasmic signal transduction pathways by a number of growth factors and their tyrosine–kinase receptors, including hepatocyte growth factor/scatter factor (HGF/SF) and itsExpand
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Intratumoral microvessel density predicts local treatment failure of radically irradiated squamous cell cancer of the oropharynx.
PURPOSE To determine the predictive value of intratumoral microvessel density (IMD), and of the expression of p53, vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP-1) for theExpand
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Extracellular Signal-Regulated Kinase 1c (ERK1c), a Novel 42-Kilodalton ERK, Demonstrates Unique Modes of Regulation, Localization, and Function
ABSTRACT Extracellular signal-regulated kinases (ERKs) are signaling molecules that regulate many cellular processes. We have previously identified an alternatively spliced 46-kDa form of ERK1 thatExpand
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