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- Publications
- Influence
Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells
- J. Mora, M. Iwata, +10 authors U. V. von Andrian
- Biology, Medicine
- Science
- 17 November 2006
Normal intestinal mucosa contains abundant immunoglobulin A (IgA)–secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from… Expand
The gut microbiota and host health: a new clinical frontier
- J. Marchesi, D. Adams, +10 authors A. Hart
- Medicine
- Gut
- 2 September 2015
Over the last 10–15 years, our understanding of the composition and functions of the human gut microbiota has increased exponentially. To a large extent, this has been due to new ‘omic’ technologies… Expand
Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
- D. Adams, B. Eksteen
- Biology, Medicine
- Nature Reviews Immunology
- 1 March 2006
Active inflammatory bowel disease (IBD) is often associated with simultaneous inflammation in the skin, eyes and joints. Inflammatory disease in the liver can also occur in patients with IBD but… Expand
Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver.
- P. L. Shields, C. Morland, M. Salmon, S. Qin, S. Hubscher, D. Adams
- Biology, Medicine
- Journal of immunology
- 1 December 1999
The role played by chemokines in regulating the selective recruitment of lymphocytes to different tissue compartments in disease is poorly characterized. In hepatitis C infection, inflammation… Expand
Chemokines: leucocyte recruitment and activation cytokines
- D. Adams, Andrew Rlloyd
- Biology, Medicine
- The Lancet
- 15 February 1997
Chemokines are a family of structurally related proteins that share the ability to induce migration of specific subsets of leucocytes. These specialised cytokines play a critical part in the… Expand
Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties
- E. Billerbeck, Yu-Hoi Kang, +21 authors P. Klenerman
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 28 January 2010
CD8+ T lymphocytes play a key role in host defense, in particular against important persistent viruses, although the critical functional properties of such cells in tissue are not fully defined. We… Expand
MAdCAM‐1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM‐1 in chronic inflammatory liver disease)
- A. Grant, P. Lalor, S. Hübscher, M. Briskin, D. Adams
- Medicine
- Hepatology
- 1 May 2001
Mucosal addressin cell adhesion molecule (MAdCAM‐1) plays a pivotal role in T‐lymphocyte homing to the gut. Given the strong association between the autoimmune liver diseases primary sclerosing… Expand
Interleukin-10 secretion differentiates dendritic cells from human liver and skin.
- S. Goddard, J. Youster, E. Morgan, D. Adams
- Biology, Medicine
- The American journal of pathology
- 1 February 2004
Liver dendritic cells (DCs), which may orchestrate the liver's unique immunoregulatory functions, remain poorly characterized. We used a technique of overnight migration from pieces of normal human… Expand
CXC Chemokine Ligand 16 Promotes Integrin-Mediated Adhesion of Liver-Infiltrating Lymphocytes to Cholangiocytes and Hepatocytes within the Inflamed Human Liver1
- M. Heydtmann, P. Lalor, J. Eksteen, S. Hübscher, M. Briskin, D. Adams
- Biology, Medicine
- The Journal of Immunology
- 15 January 2005
Lymphocyte recruitment to the liver is critical for viral clearance in acute hepatitis and in the pathogenesis of chronic inflammatory liver disease when persistent chronic inflammation leads to… Expand
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.
- L. Walker, Yu-Hoi Kang, +15 authors P. Klenerman
- Biology, Medicine
- Blood
- 12 January 2012
Human mucosal associated invariant T (MAIT) CD8(+) and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161 ((++)) and type-17 differentiation, but their… Expand