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Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells
Normal intestinal mucosa contains abundant immunoglobulin A (IgA)–secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) fromExpand
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The gut microbiota and host health: a new clinical frontier
Over the last 10–15 years, our understanding of the composition and functions of the human gut microbiota has increased exponentially. To a large extent, this has been due to new ‘omic’ technologiesExpand
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Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
Active inflammatory bowel disease (IBD) is often associated with simultaneous inflammation in the skin, eyes and joints. Inflammatory disease in the liver can also occur in patients with IBD butExpand
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Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver.
The role played by chemokines in regulating the selective recruitment of lymphocytes to different tissue compartments in disease is poorly characterized. In hepatitis C infection, inflammationExpand
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Chemokines: leucocyte recruitment and activation cytokines
Chemokines are a family of structurally related proteins that share the ability to induce migration of specific subsets of leucocytes. These specialised cytokines play a critical part in theExpand
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Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties
CD8+ T lymphocytes play a key role in host defense, in particular against important persistent viruses, although the critical functional properties of such cells in tissue are not fully defined. WeExpand
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MAdCAM‐1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM‐1 in chronic inflammatory liver disease)
Mucosal addressin cell adhesion molecule (MAdCAM‐1) plays a pivotal role in T‐lymphocyte homing to the gut. Given the strong association between the autoimmune liver diseases primary sclerosingExpand
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Interleukin-10 secretion differentiates dendritic cells from human liver and skin.
Liver dendritic cells (DCs), which may orchestrate the liver's unique immunoregulatory functions, remain poorly characterized. We used a technique of overnight migration from pieces of normal humanExpand
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CXC Chemokine Ligand 16 Promotes Integrin-Mediated Adhesion of Liver-Infiltrating Lymphocytes to Cholangiocytes and Hepatocytes within the Inflamed Human Liver1
Lymphocyte recruitment to the liver is critical for viral clearance in acute hepatitis and in the pathogenesis of chronic inflammatory liver disease when persistent chronic inflammation leads toExpand
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Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.
Human mucosal associated invariant T (MAIT) CD8(+) and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161 ((++)) and type-17 differentiation, but theirExpand
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