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Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells
It is shown that dendritic cells from GALT induce T cell–independent expression of IgA and gut-homing receptors on B cells, which shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.
The gut microbiota and host health: a new clinical frontier
The potential of manipulating the gut microbiota in these disorders is assessed, with an examination of the latest and most relevant evidence relating to antibiotics, probiotics, prebiotics, polyphenols and faecal microbiota transplantation.
Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties
- E. Billerbeck, Yu-Hoi Kang, P. Klenerman
- Biology, MedicineProceedings of the National Academy of Sciences
- 28 January 2010
A T cell lineage that is present already in cord blood and represents as many as one in six circulating CD8+ T cells in normal humans and a substantial fraction of tissue-infiltrating CD8-T cells in chronic inflammation is defined.
Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell–mediated liver damage
It is demonstrated that this non-antigen–specific mechanism can be switched on by cytokines produced during active HBV infection and concluded that NK cells may contribute to liver inflammation by TRAIL-mediated death of hepatocytes.
Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
It is proposed that the hepatic complications of IBD are mediated by long-lived mucosal T cells that are recruited to the liver in response to aberrantly expressed endothelial-cell adhesion molecules and chemokines that are normally restricted to the gut.
Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver.
- P. Shields, C. Morland, M. Salmon, S. Qin, S. Hubscher, D. Adams
- Biology, MedicineJournal of immunology
- 1 December 1999
It is proposed that intrahepatic Th1 cytokines drive the increased expression of IFN-inducible protein-10 and monokine-induced byIFN-gamma and thereby promote the continuing recruitment of CXCR3-expressing T cells into the hepatic lobule in chronic hepatitis C infection.
Sleisenger and Fordtran’s Gastrointestinal and Liver Disease
- D. Adams
- 11 July 2007
The 8th edition of this famous textbook is the first not to be edited by either of the original editors and the 3rd edition to include hepatology as well as gastroenterology, with 38 of the 124 chapters focused on liver and biliary disease.
Chemokines: leucocyte recruitment and activation cytokines
Hepatic Endothelial CCL25 Mediates the Recruitment of CCR9+ Gut-homing Lymphocytes to the Liver in Primary Sclerosing Cholangitis
It is shown that liver-infiltrating lymphocytes in PSC include mucosal T cells recruited to the liver by aberrant expression of the gut-specific chemokine CCL25 that activates α4β7 binding to mucosal addressin cell adhesion molecule 1 on the hepatic endothelium, the first demonstration in humans that T cells activated in the gut can be recruited to an extra-intestinal site of disease.