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Nested expression domains of four homeobox genes in developing rostral brain
The expression domains of the four genes in the developing rostral brain of mouse embryos at a developmental stage, day 10 post coitum, seem to be continuous regions contained within each other in the sequence Emxl < Emx2 < Otxl< Otx2. Expand
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.
The expression patterns of the two genes in diencephalon suggest that they both have a role in establishing the boundary between presumptive dorsal and ventral thalamus and in anterior neuroectoderm, demarcating rostral brain regions even before headfold formation. Expand
Reorganization of enhancer patterns in transition from naive to primed pluripotency.
It is demonstrated that transition between these two pluripotent states is associated with widespread Oct4 relocalization, mirrored by global rearrangement of enhancer chromatin landscapes, and suggested that the capacity of transcription factors such as Otx2 and Oct4 to pioneer new enhancer sites is highly context dependent. Expand
Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.
It is suggested that Otx2 expression in endomesoderm and ectoderm is required for anterior neuroectoderm specification, and in gastrulating heterozygous embryos, a post-transcriptional repression acts on lacZ transcripts in the ectodermal layer, but not in the external layer, suggesting that different post- transcriptional mechanisms control Otx1 expression in both layers. Expand
Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.
We cloned two homeobox genes, Emx1 and Emx2, related to empty spiracles, a gene expressed in very anterior body regions during early Drosophila embryogenesis, and studied their expression in mouseExpand
Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.
The defects observed in Dlx5-/- mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation. Expand
Otx genes are required for tissue specification in the developing eye.
A model is proposed in which Otx gene products are required for the determination and differentiation of the pigment epithelium, co-operating with other eye patterning genes in the determination of the specialised tissues that will constitute the mature vertebrate eye. Expand
Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.
Evidence is provided that the difference between Otx1 and Otx2 null mice phenotypes originates from their divergent expression patterns, and it is hypothesized that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification. Expand
Cloning and characterization of two members of the vertebrate Dlx gene family.
The expression pattern of these genes, together with their chromosome localization, may provide useful cues for the study of congenital disorders in which there is a combination of craniofacial and limb defects. Expand
Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene.
The data provide evidence that Otp and Sim1, a bHLH-PAS transcription factor that directs terminal differentiation of the PVN, SON, and aPV, act in parallel and are both required to maintain Brn2 expression which, in turn, is required for neuronal cell lineages secreting oxytocin (OT), arginine vasopressin (AVP), and corticotropin-releasing hormone (CRH). Expand