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Influence of glutathione S-transferase polymorphisms on type-2 diabetes mellitus risk.
Glutathione S-transferase (GST) protects cells against oxidative stress. We evaluated the effect of genetic polymorphisms of the GST gene family on the risk of developing type-2 diabetes mellitus andExpand
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Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies.
Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that limits the clinical use of cisplatin as an anti-tumoral drug. Our study was conducted to evaluate theExpand
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Acetyl-l-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy
Although the mechanisms of neurodegeneration in Parkinson's disease are not fully understood, mitochondrial dysfunction, oxidative stress and environmental toxins may be involved. The currentExpand
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Piracetam and vinpocetine ameliorate rotenone-induced Parkinsonism in rats
Objective: To evaluate the neuroprotective effect of the nootropic drugs, piracetam (PIR) and vinpocetine (VIN), in rotenone-induced Parkinsonism in rats. Materials and Methods: Sixty male rats wereExpand
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Bacterial Community Analyses of Two Red Sea Sponges
Red Sea sponges offer potential as sources of novel drugs and bioactive compounds. Sponges harbor diverse and abundant prokaryotic communities. The diversity of Egyptian sponge-associated bacterialExpand
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Effect of metabolites isolated from Cuscutapedicellata on high fat diet-fed rats
AbstractThe aim of the present study was to determine if Cuscuta pedicellata extract has an effect on body weight and serum lipid profile in the HFD-fed rats’ animal model. The ethanol extract of C.Expand
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C-reactive protein 1059G/C gene polymorphism, C-reactive protein levels and acute myocardial infarction
Aims High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker, predicting the occurrence of acute myocardial infarction (AMI). Genetic predisposition to high baseline CRP might accountExpand
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Evaluation of glutathione S-transferase P1 genetic variants affecting type-2 diabetes susceptibility and glycemic control
Introduction Type 2 diabetes mellitus (T2DM) is associated with increased production of reactive oxygen species and a reduction in antioxidant defenses leading to oxidative stress. GlutathioneExpand
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Atorvastatin restores the balance between pro-inflammatory and anti-inflammatory mediators in rats with acute myocardial infarction.
BACKGROUND Pro- and anti-inflammatory cytokines play a major role in the development of acute myocardial infarction (AMI). This paper tests the hypothesis that atorvastatin may attenuate the severityExpand
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Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina (Forssk.) Fiori in cervical and prostate cancer cell lines.
OBJECTIVE This study investigated cytotoxicity and induction of apoptosis in human cervical cancer cells (HELA) and prostate cancer cells (PC-3) using the most active fraction of Moringa peregrinaExpand
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