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Influence of glutathione S-transferase polymorphisms on type-2 diabetes mellitus risk.
TLDR
Evidence is given that the GSTT1- and GSTM1-null genotypes, alone or combined, are associated with increased risk of type-2 diabetes mellitus, regardless of smoking status.
Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies.
Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that limits the clinical use of cisplatin as an anti-tumoral drug. Our study was conducted to evaluate the
Acetyl-l-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy
TLDR
This study reinforces the view that acetyl-L-carnitine and α-lipoic acid are promising candidates for neuroprotection in Parkinson's disease.
Piracetam and vinpocetine ameliorate rotenone-induced Parkinsonism in rats
TLDR
VIN and PIR exhibit neuroprotective activity in rotenone-induced Parkinsonism and may be considered as possible candidates in the treatment of Parkinson's disease.
Bacterial Community Analyses of Two Red Sea Sponges
TLDR
This study is the first culture-based and culture-independent investigation of the total bacterial assemblages associated with two Red Sea Demosponges, Hyrtios erectus and Amphimedon sp, and provides an excellent resource of several candidate bacteria for production of novel pharmaceutically important compounds.
C-reactive protein 1059G/C gene polymorphism, C-reactive protein levels and acute myocardial infarction
TLDR
It was revealed that CRP 1059G/C gene variation influences plasma CRP levels, and this polymorphism was not associated with the risk for AMI.
Atorvastatin restores the balance between pro-inflammatory and anti-inflammatory mediators in rats with acute myocardial infarction.
TLDR
This study suggests the usefulness of atorvastatin as an attenuating agent against AMI and restores the balance between the pro-inflammatory and the anti-inflammatory mediators and modulates the fibrinolysis by reducing the levels of PAI-1.
Evaluation of glutathione S-transferase P1 genetic variants affecting type-2 diabetes susceptibility and glycemic control
TLDR
GSTP1 gene polymorphism may play a significant role in increasing the susceptibility to and risk of T2DM and obesity regardless of smoking status and had no apparent effect on HbA1c in patients with diabetes mellitus.
Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina (Forssk.) Fiori in cervical and prostate cancer cell lines.
TLDR
Seed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HELA and PC-3 cells, and the selectivity index indicated that CFEE had a high degree of selectivity against HEL a and PC3 cells.
Effect of metabolites isolated from Cuscutapedicellata on high fat diet-fed rats
AbstractThe aim of the present study was to determine if Cuscuta pedicellata extract has an effect on body weight and serum lipid profile in the HFD-fed rats’ animal model. The ethanol extract of C.
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