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Nonselective Persistence of a Rickettsia conorii Extrachromosomal Plasmid during Mammalian Infection
- Sean P. Riley, Abigail I. Fish, +4 authors J. Martínez
- Biology, MedicineInfection and Immunity
- 11 January 2016
It is demonstrated that the presence of an extrachromosomal DNA element in a pathogenic rickettsial species does not affect either in vitro proliferation or in vivo infectivity in models of disease and that plasmids such as pRam18dRGA[AmTrCh] are valuable tools for the further genetic manipulation of pathogenic R. conorii.
Expression of Rickettsia Adr2 protein in E. coli is sufficient to promote resistance to complement-mediated killing, but not adherence to mammalian cells
Bacteria exposed to host serum are subject to the antibacterial effects to the complement system. However, pathogenic microorganisms have evolved mechanisms of evading this immune attack. We have…