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Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B(1)-treated rats.
The effect of ochratoxin A (OTA), fumonisin B(1) (FB(1)), and their combinations on DNA damage was studied using the standard alkaline comet assay and the Fpg-modified comet assay. Rats were orally… Expand
Cytogenetic monitoring of croatian population occupationally exposed to a complex mixture of pesticides.
This paper describes a longitudinal study of possible genetic damage in Croatian workers occupationally exposed to a complex mixture of pesticides. The methods of choice were chromosomal aberration… Expand
A potential role of calcium in apoptosis and aberrant chromatin forms in porcine kidney PK15 cells induced by individual and combined ochratoxin A and citrinin
- M. Š. Klarić, D. Želježić, L. Rumora, M. Peraica, S. Pepeljnjak, Ana-Marija Domijan
- Biology, Medicine
- Archives of Toxicology
The aim of this study was to establish the involvement of calcium signalling in genotoxicity, apoptosis and necrosis evoked by ochratoxin A (OTA) and citrinin (CTN) alone or in combination in porcine… Expand
Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: a multi-biomarker approach.
- N. Kopjar, V. Garaj-Vrhovac, +4 authors D. Želježić
- International journal of hygiene and…
- 1 July 2009
The aim of the present study was to evaluate genome damage induced in peripheral blood lymphocytes of Croatian health care workers occupationally exposed to cytotoxic drugs. A comprehensive… Expand
Chromosomal aberrations, micronuclei and nuclear buds induced in human lymphocytes by 2,4-dichlorophenoxyacetic acid pesticide formulation.
Pesticides of worldwide application are used in agriculture in vast amounts each year, of which herbicides are the most prominent class. Phenoxyacetic herbicides constitute one of the largest groups… Expand
Evaluation of genome damage and its relation to oxidative stress induced by glyphosate in human lymphocytes in vitro
- M. Mladinić, S. Berend, A. Vrdoljak, N. Kopjar, B. Radić, D. Želježić
- Medicine, Biology
- Environmental and molecular mutagenesis
- 1 December 2009
In the present study we evaluated the genotoxic and oxidative potential of glyphosate on human lymphocytes at concentrations likely to be encountered in residential and occupational exposure. Testing… Expand
Chromosomal aberration and single cell gel electrophoresis (Comet) assay in the longitudinal risk assessment of occupational exposure to pesticides.
In recent years the use of pesticides in agriculture has been increasing steadily. At present there are more than 1000 chemicals classified as pesticides. Therefore, the widespread use of pesticides… Expand
Evaluation of DNA damage induced by atrazine and atrazine-based herbicide in human lymphocytes in vitro using a comet and DNA diffusion assay.
- D. Želježić, V. Garaj-Vrhovac, P. Perković
- Biology, Medicine
- Toxicology in vitro : an international journal…
- 1 September 2006
Atrazine is one of the most widely used herbicides in the world. When applied, it is not used as a pure active ingredient but in the form of commercial formulations. Besides atrazine, these… Expand
Evaluation of genotoxic effects of lead in pottery-glaze workers using micronucleus assay, alkaline comet assay and DNA diffusion assay
- V. Kašuba, R. Rozgaj, +5 authors A. Jazbec
- Chemistry, Medicine
- International Archives of Occupational and…
PurposeWe investigated genotoxic effects of occupational exposure to lead acetate in pottery-glaze ceramic workers.MethodsThe study was carried out in 30 exposed workers and 30 matched controls, to… Expand
DNA damage by ochratoxin A in rat kidney assessed by the alkaline comet assay.
There are few studies of ochratoxin A (OTA) genotoxicity in experimental animals and the results obtained with cell cultures are inconsistent, although the carcinogenic potential of OTA for the… Expand