D. van der Waaij

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A new way of measuring indirect immunofluorescence (IIF) of microscopic bacterial slide preparations by videocamera and an image processing system is presented. This method is compared with the conventional method of reading the slides by eye. The advantages of this new approach are objective reading, greater accuracy and easier performance. We have applied(More)
In the present study we investigated the occurrence of delayed-type graft-versus-host disease (DT-GvHD) after allogeneic bone marrow transplantation (BMT) between two H-2 incompatible mouse strains. BMT was performed on mice with a conventional intestinal microflora as well as on mice in which the Enterobacteriaceae were selectively eliminated from the(More)
s should be submitted before January 15, 1987. Notification of selection will be mailed by March 31, 1987 Requests for hotel accommodation cannot be guaranteed after February I, 1987. Requests for changes in hotel reservations and hotel cancellations cannot be guaranteed after March l, 1987. All correspondence and enquiries should be addressed to: Third(More)
One of the major complications of allogeneic bone marrow transplantation (BMT) is graft-versus-host disease (GvHD), which is caused by donor type lymphocytes which react against the recipient’s tissues. An important factor which influences GvHD is the recipient's gastrointestinal microflora. This was originally observed in gnotobiotic mice. Infusion of 107(More)
Oral treatment of mice with a combination of non-absorbable broad spectrum antibiotics at a dose level high enough to sterilize the digestive tract within five days of treatment, has been found to have a significant negative effect on the relative weight of the thymus. From the age of 12 weeks onwards, the mean relative weight of the thymus of conventional(More)
The interaction between the intestinal flora and the immune system is complex, and as yet little understood. The Groningen Reduction of Image Data (GRID) image processing system is a relatively new tool in the investigation of this interaction. The image processing approach allows measurement of morphological and immunological characteristics of faecal(More)
Results of several of our studies performed in last two decades regard the development and value of the intestinal colonisation resistance (CR) for baby mice as well as its ‘clinical’ consequences in this animal species. Before weaning the CR has been found to be low in comparison with adult animal but still of great importance to the health and survival of(More)
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