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· Background: This long-term (2.3 years) study determines the temporal relationship between systemic glucose levels and the progression of diabetic retinopathy during the natural course of streptozotocin-induced diabetes in rats. · Methods: Of 367 rats, 200 were randomly assigned into a group injected with streptozotocin (50 mg.kg–1) and 167 into a control(More)
The peptide surfactants are amphiphilic peptides which have a hydrophobic tail and a hydrophilic head, and have been reported to stabilize and protect some membrane proteins more effectively than conventional surfactants. The effects of a class of peptide surfactants on the structure and thermal stability of the photosynthetic membrane protein(More)
Measurements of vitreal oxygen tension have been made for the first time in the streptozotocin-induced diabetic rat eye. A total of 36 Sprague Dawley rats were divided into a control (n=18) and streptozotocin injected group (n=18), and after 5–6 weeks of established hyperglycaemia, an acute experiment was performed in which vitreal oxygen tension profiles(More)
Retinal diseases with a vascular component account for the majority of blindness in the developed world. The vulnerability of the retina stems in part from the limitations placed on the retinal vascular system to not obstruct the light path to the photoreceptors. Some layers of the retina are completely avascular, and in our central region of vision, the(More)
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