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Bone remodelling maintains the functionality of skeletal tissue by locally coordinating bone-resorbing cells (osteoclasts) and bone-forming cells (osteoblasts) in the form of Bone Multicellular Units (BMUs). Understanding the emergence of such structured units out of the complex network of biochemical interactions between bone cells is essential to extend(More)
Denosumab, a fully human monoclonal antibody, has been approved for the treatment of postmenopausal osteoporosis. The therapeutic effect of denosumab rests on its ability to inhibit osteoclast differentiation. Here, we present a computational approach on the basis of coupling a pharmacokinetics model of denosumab with a pharmacodynamics model for(More)
Knowledge of location and magnitude of charge density, together with the pore morphology allows one to calculate the Donnan potential, characterizing ion exclusion in charged porous materials. Use of the electro-chemical potential together with Gauss' electrostatic theorem allows the computation of the ion and voltage distribution at the mi-croscale. On the(More)
The development of EDATA2 was stimulated by the proliferation of mixed energy dispersive/wavelength dispersive equipped electron microprobes. For such systems to be operated most efficiently and conveniently, a data reduction program is required that can handle energy-dispersive, wavelength-dispersive, or a mixture of both kinds of data. This requirement(More)
Bone remodeling involves the coordinated removal of bone by osteoclasts and addition of bone by osteoblasts, a process that is modulated by the prevailing mechanical environment. In this paper a fully coupled model of bone remodeling is developed, based on coupling a bone cell population model with a micromechanical homogenization scheme of bone stiffness.(More)
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