D W Manuel

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To provide a noninvasive means for studying individual macroscopic blood vessels, an ultrasound scanner was modified to provide a recording of blood vessel diameter. The instrument has A- and B-modes of signal display. The B-mode is used to position the probe and the A-mode to measure vessel diameter. The A-mode has two electronic gates for tracking the(More)
BACKGROUND AND PURPOSE IL-13 is a pleiotropic Th2 cytokine considered likely to play a pivotal role in asthma. Here we describe the preclinical in vitro and in vivo characterization of CAT-354, an IL-13-neutralizing IgG4 monoclonal antibody (mAb), currently in clinical development. EXPERIMENTAL APPROACH In vitro the potency, specificity and species(More)
Since human endothelial cells synthesize Factor V but do not secrete it into the medium, we studied the effects of cell injury on the availability of Factor V at the surface of these cells. Human umbilical vein endothelial cells (HUVEC), grown to confluency and incubated with human 125I Factor Va, specifically bound 5000 to 7000 molecules per cell. In the(More)
s P1 P16 are educational and not included for publication online P2 Abstracts P1 P16 are educational and not included for publication online Breast Cancer Research 2012, 14(Suppl 1):P2 Abstracts P1 P16 are educational and not included for publication onlines P1 P16 are educational and not included for publication online P3 Abstracts P1 P16 are educational(More)
s P1 P16 are educational and not included for publication online P2 Abstracts P1 P16 are educational and not included for publication online Breast Cancer Research 2012, 14(Suppl 1):P2 Abstracts P1 P16 are educational and not included for publication onlines P1 P16 are educational and not included for publication online P3 Abstracts P1 P16 are educational(More)
s P1 P16 are educational and not included for publication online P2 Abstracts P1 P16 are educational and not included for publication online Breast Cancer Research 2012, 14(Suppl 1):P2 Abstracts P1 P16 are educational and not included for publication onlines P1 P16 are educational and not included for publication online P3 Abstracts P1 P16 are educational(More)
BACKGROUND Tailoring neoadjuvant chemotherapy (NAC) during breast cancer treatment is performed to improve overall tumour response, with increasing evidence to support its role. This study evaluates our breast unit's experience in MRI assessment of tumour response as an aid in tailoring NAC. MATERIALS AND METHODS This is a retrospective study of patients(More)
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