D W Golding

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Neurons are now known to produce a variety of types of chemical transmitters. Classical transmitters are stored within synaptic vesicles which undergo synaptic exocytosis in association with presynaptic thickenings. The larger, dense-cored secretory granules present in most neurons contain neuropeptides and mainly discharge their contents at morphologically(More)
Most nerve terminals forming typical synaptic junctions contain both synaptic vesicles and larger 'secretory granules' with electron-dense contents. Visualization of granule exocytosis from within terminals in the corpus cardiacum is facilitated by injection of tannic acid which immobilizes granule cores as they are discharged. The process of discharge is(More)
Nerve fibers within the large pancreatic islet of Xiphophorus helleri are apparently of a single type and form typical, well-differentiated synapses with the endocrine gland cells. A histochemical test for cholinesterases generates reaction product in association with the outer surfaces of the neuronal membranes. Two categories of presumptive secretory(More)
Secretory end-feet (or SEF) systems are present in Limnodrilus and Stylodrilus but are less highly organized than those of polychaetes. SEF contain secretory vesicles and abundant mitochondria. Typical neurosecretory terminals are not found within the brain although "neurosecretory" perikarya are present in all four species studied. In Limnodrilus,(More)
The adrenal chromaffin gland of the goldfish has typical synaptic terminals embedded in its surface which are homologues of the cholinergic fibres innervating the mammalian adrenal medulla. The terminals contain both lucent synaptic vesicles and larger secretory granules with dense cores, known to be storage sites for transmitters and peptides,(More)
Nerve fibres form conventional synaptic junctions with gland cells in the corpus cardiacum of the locust, Schistocerca gregaria. They contain synaptic vesicles whose contents are normally electron-lucent, but which react positively to cytochemical tests for amines (eg, incubation in the false transmitter 5-OHDA). Secretory granules are also present in the(More)
Neurosecretory cells in the mollusc Helix have perikarya that show clear signs of adaptation for both the synthesis and the discharge of secretory material. They are characterized morphologically by juxtaposition with the neural lamella. Passage of hormone into the haemocoel is apparently facilitated in many cases by the extreme attenuation of areas of the(More)
Nerve terminals forming typical synapses with adrenal chromaffin tissues have been examined in the goldfish, frog (Rana pipiens), hamster and rat. Presumptive secretory inclusions present in the terminals are of two distinct types. Electron-lucent synaptic vesicles 30-50 nm in diameter are densely clustered adjacent to membrane thickenings and presumably(More)
The sinus gland of Carcinus maenas contains small numbers of neurosecretory neurones ("intrinsic cells") as well as glial cells and nerve terminals. Intrinsic cells may be of the same cell type as some extrinsic cells, but are probably multipolar. Exocytosis is a common phenomenon, and may be either "basal" or "interterminal", and either "simple" or(More)
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