D W Ashcroft

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OBJECTIVES To consider the effectiveness and cost-effectiveness of pimecrolimus for mild to moderate atopic eczema and tacrolimus for moderate to severe atopic eczema compared with current standard treatment in adults and children. DATA SOURCES Electronic databases. Experts and the manufacturers of these agents were also approached for information. (More)
BACKGROUND The burden of psoriasis across many world regions is high and there is a recognized need to better understand the epidemiology of this common skin disorder. OBJECTIVES To examine changes in the prevalence and incidence of psoriasis, and mortality rates over a 15-year period. METHODS Cohort study involving analysis of longitudinal electronic(More)
Concerns have been raised regarding an increased risk of major adverse cardiovascular events (MACEs) (myocardial infarction, cerebrovascular accident or cardiovascular death) in patients treated with anti-interleukin (IL)-12/23 agents for moderate-to-severe psoriasis. We aimed to examine the risk of MACEs in adult patients with plaque psoriasis that are(More)
BACKGROUND Medication nonadherence is known to limit the effectiveness of available therapies; however, little is known specifically about medication adherence in people with psoriasis. Medicines self-management can feel onerous to those with dermatological conditions due to the nature of therapies prescribed and many individuals with psoriasis experience(More)
OBJECTIVES To review outcome measures and treatment costs in children with juvenile idiopathic arthritis (JIA) and low bone mineral density (BMD) and/or fragility fractures. To review evidence for effectiveness and safety of bisphosphonates and calcium and/or vitamin D in these children. To assess long-term bone health in adults with JIA. DATA SOURCES(More)
Congenital atresia of posterior choanae is a moderately rare condition, and although Boyd (1945) has accounted for 230 cases in the literature, description of the symptoms presenting at birth are very scanty. Unilateral choanal obstruction is very much more common than the complete bilateral obstruction that was found in the present case. Richardson (1913)(More)
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