D. Vasileiou

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The statistical identification of the isochore structure, the variation in large scale GC composition, of mammalian genomes is a necessary requirement for understanding both the evolution of base composition and the many genomic features such as mutation and recombination rates which covary with base composition. We have developed a Bayesian method for(More)
When several treatments are available for evaluation in a clinical trial, different design options are available. We compare multi-arm multi-stage with factorial designs, and in particular, we will consider a 2 × 2 factorial design, where groups of patients will either take treatments A, B, both or neither. We investigate the performance and characteristics(More)
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