D. V. Kuyavskaya

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In all secreted proteins related to the epidermal growth factor (EGF), EGF domains that occur in a mature factor are each encoded by two exons, and those that do not, by one exon. During splicing, additional exon 3a can be inserted between exons 3 and 4, which code for the EGF domain of the mature heparin-binding EGF-like growth factor (HB-EGF). The(More)
Flow cytometry (FCM) analysis of live antibody-coated spermatozoa subjected to immunofluorescence staining (FCM test) is considered an objective method for the quantitative detection of antisperm antibodies (ASA). But the cross-linking of cell surface antigen (Ag) with bivalent antibodies and/or antigen-antibody (Ag-Ab) complexes with second antibodies may(More)
It is demonstrated that in the presence of human recombinant γ-interferon and C-reactive protein the activity of natural killers increases 9–43%, whereas the number of effector:target cell conjugates formed at the stage of recognizing and binding of target cells decreases 14–80%. There is a weak positive correlation (ρ=0.35) between the activity of natural(More)
The levels of antispermal antibodies in the sera of women varied within a wide range when spermatozoa from different donors were used. This was probably due to expression of different antigenic structures on the surface of spermatozoa of fertile and sterile men and their different specificity for the tested female serum. Spermatozoa from different donors(More)
Antispermal antibodies were detected by flow cytofluorimetry and mixed antiglobulin reaction (MAR). The results of the two methods significantly correlated regarding serum IgG antispermal antibodies under conditions ruling out capacitation of spermatozoa. There were no significant differences in the content of antispermal antibodies in the sera of fertile,(More)
The cytotoxic activity of natural killer cells and the intensity of conjugate formation are studiedin vitro in the natural cytotoxicity reaction against3H-uridine-labeled human erythromyeloleukotic cells K-562 in the presence of fibronectin, γ-globulin, and fibronectin/γ-globulin combination. It is demonstrated that fibronectin does not change natural(More)
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