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Three members of a collection of pBR322-yeast DNA recombinant plasmids containing yeast tRNA genes have been analyzed and sequenced. Each plasmid carries a single tRNA gene: pY44, tRNA(2); pY41, tRNA(2); pY7, tRNA(1). All three genes are intronless and terminate in a cluster of Ts in the non-coding strand. The sequence information here and previously(More)
We have studied 2 patients with de novo deletion 1 (q42.3----qter): a 5 1/2-year-old boy and an unrelated 1 9/12-year-old girl. The analysis of the phenotype which is now possible in a total of 23 cases shows that the deletion of the terminal 1q leads to a definable multiple congenital anomalies/mental retardation (MCA/MR) syndrome. The phenotype is so(More)
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