D Szlabowicz

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Bovine serum albumin has two different binding sites for sulfonylurea. The sites at high affinity can bind up to 2 moles of a new hypoglycemic sulfonylurea SPC-703 (k1=6.8.10(3) M(-1)) or tolbutamide K1=19.3.10(3) M(-1)). The sites of lower affinity can bind 4 mole of SPC-703 (K2=1.6.10(3) M(-1)) or 8 moles of tolbutamide (k2=1.3.10(3) M(-1)). Binding of(More)
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