A unified design representation can work. This has always been considered impractical due to major problems of run time, space, tool interdependencies, and multiple representations. We have addressed these problems and found them tractable. We present our solutions to these problems, gained through the experience of developing the Droid design system.
Open or uncontrolled studies have suggested that providing cancer patients with audiotapes of their clinical interviews can improve information recall and reduce psychological distress. We tested these hypotheses in a 'clinician-blind', prospective, randomised controlled trial. A total of 117 patients newly referred to a medical oncology clinic who were to… (More)
In recent years, controversy has arisen regarding the risks and benefits of certain types of gain-of-function (GOF) studies involving avian influenza viruses. In this article, we provide specific examples of how different types of data, including information garnered from GOF studies, have helped to shape the influenza vaccine production process-from… (More)
The inherent or acquired (induced) resistance of certain tumours to cytotoxic drug therapy is a major clinical problem. There are many categories of cytotoxic agent: the antimetabolites, e.g. methotrexate (MTX), N-phosphonacetyl-L-aspartate (PALA), 5-fluorouracil (5-FU), 6-mercaptopurine (6-TG), hydroxyurea (HU) and 1-beta-D-arabinofuranosylcytosine (AraC);… (More)
More than 540 serologically confirmed cases of Ross River (RR) virus disease have been reported from the southwest region of Western Australia since November 1995 (Figure 1). Most affected by the mosquito-borne disease are communities on the Swan Coastal Plain south of Perth. Cases have also been reported from towns farther south or inland and from Perth… (More)
Resumo Descrevemos neste artigo a nossa experiência no uso de um formalismo visual, chamado JASMINUM , qué e usado na etapa de design da interface com o usuário de um editor de documentos estruturado chamado Waterloo Rita. JASMINUM combina conceitos de Abstract Data Views com as notações de Objectcharts, Statecharts e redes de Petri. JASMINUM foi motivado… (More)
Acute viral hepatitis affects all ages worldwide. Hepatitis E virus (HEV) is increasingly recognized as a major cause of acute hepatitis in Europe. Because knowledge of its characteristics is limited, we conducted a retrospective study to outline demographic and clinical features of acute HEV in comparison to hepatitis A, B and C in Lothian over 28 months… (More)