D. Silva

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OBJECTIVES This study aimed to investigate the activity of the combination of topical paromomycin gel and oral miltefosine for the treatment of experimental cutaneous leishmaniasis caused by Leishmania (Leishmania) major. METHODS The efficacy of the combination, evaluated by measuring lesion size and parasite burden in the skin and spleen, was assessed in(More)
Sir, Extended-spectrum b-lactamase (ESBL)-producing Enterobacte-riaceae have been recognized as significant nosocomial pathogens during recent decades. 1 The spread of these organisms is worrisome since they might also transfer antibiotic resistance genes among different hosts and environments. In this work, we describe the occurrence of ESBLs and integrons(More)
BACKGROUND The consequences of alcohol dependence are severe and may range from physical disease to neuropsychological deficits in several cognitive domains. Alcohol abuse has also been related to brain dysfunction specifically in the prefrontal cortex. Conventional neuropsychological interventions (paper-and-pencil cognitive stimulation training) have a(More)
Atopic dermatitis (AD) is a relapsing inflammatory skin disease with a considerable social and economic burden. Functional textiles may have antimicrobial and antipruritic properties and have been used as complementary treatment in AD. We aimed to assess their effectiveness and safety in this setting. We carried out a systematic review of three large(More)
In this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially(More)
BACKGROUND Statins are known for their lipid-lowering effects and role in the treatment of atherosclerotic disease. They also have anti-inflammatory and immunomodulatory properties which could benefit asthma patients. We aimed to review the evidence on the efficacy and safety of statins in asthma-related outcomes. METHODS A systematic review of the(More)
The first total synthesis for the sponge derived (5Z,9Z)-(+/-)-2-methoxy-5,9-octadecadienoic acid, an analog of taxoleic acid, was accomplished in seven steps and in a 10% overall yield. It was again corroborated that the best strategy to prepare these cis,cis dimethylene interrupted double bonds is the double-alkyne bromide coupling reaction of(More)
BACKGROUND It is universally accepted that atherosclerosis originates in childhood and that high LDL and low HDL serum cholesterol, hypertension and obesity are some of the main risk factors. In the past few years, increasing importance has been attributed to the deleterious effect of reactive oxygen species (ROS) on lipids, on the endothelial lining of(More)
INTRODUCTION Clusters of asthma in athletes have been insufficiently studied. Therefore, the present study aimed to characterize asthma phenotypes in elite athletes using latent class analysis (LCA) and to evaluate its association with the type of sport practiced. METHODS In the present cross-sectional study, an analysis of athletes' records was carried(More)
The majority of drugs prescribed have not been tested in children and safety and efficacy of children's medicines are frequently supported by low quality of evidence. Therefore, a large percentage of prescriptions for children in the clinical daily practice are used off label. Despite the several recent legislation and regulatory efforts performed(More)