D. S. Madhumathi

Learn More
Higher Notch signaling is known to be associated with hematological and solid cancers. We developed a potential immunotherapeutic monoclonal antibody (MAb) specific for the Negative Regulatory Region of Notch1 (NRR). The MAb604.107 exhibited higher affinity for the "Gain-of-function" mutants of Notch1 NRR associated with T Acute lymphoblastic Leukemia(More)
BACKGROUND AND OBJECTIVES This cytogenetic study detects a wide variety of common, rare and novel chromosomal abnormalities in patients with hematological disorders, providing valuable diagnostic and prognostic information. MATERIALS AND METHODS We addressed the utility of the cytogenetic technique in 50 patients of pediatric acute leukemia prospectively.(More)
  • 1