D. S. Lopes

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Research aimed at developing selective drugs acting on gamma-aminobutyric acid (GABA)A receptors introduced compounds from diverse chemical classes unrelated to the 1,4-benzodiazepines, including flavonoids. These studies also revealed the potential use of inverse agonists as cognition-enhancing agents. Here we report pharmacological properties of the novel(More)
An important geometric and linear algebraic problem denoted as vector orthogonalization, fundamental to handle contact detection and contact force descriptions in engineering applications, is here considered. The problem is to find a set of linearly independent vectors that span the entire R 3 Euclidean space given only one of the base vectors. This paper(More)
As we have recently shown that GABA should be considered a putative neurotransmitter in Schistosoma mansoni, the present work aimed to search for GABAA receptors in adult worms using [3H]-flunitrazepam to label the allosteric benzodiazepine binding site which is classically present on GABAA receptor complexes. We detected a large population (Bmax=8.25+/-1.1(More)
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