D. S. Korostovtsev

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The paper is concerned with the data indicating close interaction between xanthinoxidase (Xase) and phosphodiesterase (PDE). PDE activity can be modified by affecting the activity of Xase. This effect is mediated by changes in the concentrations of endogenous xanthines. The action of PDE inhibitors, methylxanthines, is discussed from the point of view of(More)
Various by nature extreme factors (hypoxic hypoxia, CO intoxication, chemical influence, noise and hypokinesia) caused similar changes in cAMP levels in different organs of albino rats (liver, the great cerebral hemispheres, heart). There was a significant increase in cAMP concentrations during the first stages of the influence and a progressive fall when(More)
Extremal factors of different nature (hypoxic hypoxia, carbon monoxide poisoning, exposure to chemicals and to noise, hypokinesia) caused similar changes in the cyclic AMP level in the organs of albino rats (liver, cerebral hemispheres, heart). A considerable increase in the cyclic AMP concentration was found in the first stages, followed by a progressive(More)
A number of investigated cAMP derivatives are shown to inhibit the cAMP-phosphodiesterase in brain tissues of white rats in vitro. The 8-substituted aminoethylamino-derivatives proved to be effective inhibitors of the enzyme. Among them the most pronounced inhibition displayed the 8-(beta-aminoethylamino)-cAMP. In an in vitro experiment on the model of(More)
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