D. S. H. Rosenthal

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Spontaneous apoptosis in human osteosarcoma cells was observed to be associated with a marked increase in the intracellular abundance of p53. Immunoprecipitation and immunoblot analysis revealed that, together with a variety of other nuclear proteins, p53 undergoes extensive poly-(ADP-ribosyl)ation early during the apoptotic program in these cells.(More)
Opinion Polls can be used as a means to reach weak agreement, an idea introduced by the LOCKSS system [1]. In this paper, we investigate a set of protocols that achieve data resilience for the long-term using a peer-to-peer network, where mutually untrusted peers are loosely organized. Peers use Opinion Polls to heal corrupted copies of data items instead(More)
During apoptosis, DNA undergoes fragmentation and caspase-3 cleaves poly(ADP-ribose) polymerase (PARP) into both a 24-kOu fragment con taining the DNA binding domain and an 89-kDa fragment containing the catalytic and automodification domains. Atomic force microscopy re vealed that recombinant full-length PARP bound to plasmid DNA frag ments and linked them(More)
Chemotherapeutic refractoriness of advanced cutaneous melanoma may be linked with melanoma-initiating cells, also known as melanoma stem cells. This study aimed to determine relative risk of clonal dominance of the CD133+ phenotype in tissues from melanoma patients with different clinical outcomes that could be(More)
BACKGROUND Estrogen is a known growth promoter for estrogen receptor (ER)-positive breast cancer cells. Paradoxically, in breast cancer cells that have been chronically deprived of estrogen stimulation, re-introduction of the hormone can induce apoptosis. METHODOLOGY/PRINCIPAL FINDINGS Here, we sought to identify signaling networks that are triggered by(More)
Inhibitor of differentiation/DNA-binding (Id) proteins are helix-loop-helix (HLH) transcription factors. The Id protein family (Id1-Id4) mediates tissue homeostasis by regulating cellular processes including differentiation, proliferation, and apoptosis. Ids typically function as dominant negative HLH proteins, which bind other HLH proteins and sequester(More)
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