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Recent advances in single-cell techniques have provided the opportunity to finely dissect cellular heterogeneity within populations previously defined by “bulk” assays and to uncover rare cell types. In human hematopoiesis, megakaryocytes and erythroid cells differentiate from a shared precursor, the megakaryocyte-erythroid progenitor (MEP), which remains(More)
PURPOSE To compare the repeatability within anterior corneal topography measurements and agreement between measurements with the Pentacam HR rotating Scheimpflug camera and with a previously validated Placido disk-based videokeratoscope (Medmont E300). SETTING Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of(More)
It is known that the depth of focus (DOF) of the human eye can be affected by the higher order aberrations. We estimated the optimal combinations of primary and secondary Zernike spherical aberration to expand the DOF and evaluated their efficiency in real eyes using an adaptive optics system. The ratio between increased DOF and loss of visual acuity was(More)
Analysis was undertaken of the retinal image characteristics of the best-spectacle corrected eyes of progressing myopes (n = 20, mean age = 22 years; mean spherical equivalent = -3.84 D) and a control group of emmetropes (n = 20, mean age = 23 years; mean spherical equivalent = 0.00 D) before and after a 2h reading task. Retinal image quality was calculated(More)
There is some suggestion that the ability to detect blur may be altered in adults with myopia. Here, we address the question of whether children with myopia have worse blur detection than other children, and whether blur detection in myopic children is related to the rate of myopia progression. We recruited 20 myopes and 20 non-myopes aged between 8 and 12(More)
Determination of two-dimensional characteristics of the anterior surface of the eye is becoming increasingly important in modern optometry and ophthalmology practice. In particular, accurate estimation of the pupil size and centration is crucial in customized refractive surgery, corneal transplantation, and advanced contact lens fitting. The pupil(More)
PURPOSE The recently defined visual Strehl ratio that is based on the optical transfer function (VSOTF) has a number of previously unidentified limitations in its calculation that need to be addressed. METHOD The VSOTF is complex, not bounded between zero and one, and can be negative. It is also very sensitive to the presence of prisms in the wavefront(More)
PURPOSE To study the naturally occurring kinetic characteristics of corneal surface. METHODS The right eyes of three subjects (young, early presbyope, and presbyope) were examined. Cardiac signal and longitudinal corneal apex movements were simultaneously measured with electrocardiography (ECG) and a high-speed videokeratoscope, respectively. Time,(More)
We have used videokeratoscopy and wavefront sensing to investigate the contribution of the ocular surface and the effect of stimulus vergence on the microfluctuations of the wavefront aberrations of the eye. The fluctuations of the wavefront aberrations were quantified by their variations around the mean and by using power spectrum analysis. Integrated(More)
High-speed videokeratoscopy is an emerging technology that has the potential to provide new information on dynamic changes of corneal topography and tear film behaviour. We have developed a high-speed videokeratoscope that has the ability to acquire data at the rate of 50 Hz. Two major applications of the technology are considered in this paper. First, the(More)