D. Robert Iskander

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Zernike polynomials are often used as an expansion of corneal height data and for analysis of optical wavefronts. Accurate modeling of corneal surfaces with Zernike polynomials involves selecting the order of the polynomial expansion based on the measured data. We have compared the efficacy of various classical model order selection techniques that can be(More)
It is known that the depth of focus (DOF) of the human eye can be affected by the higher order aberrations. We estimated the optimal combinations of primary and secondary Zernike spherical aberration to expand the DOF and evaluated their efficiency in real eyes using an adaptive optics system. The ratio between increased DOF and loss of visual acuity was(More)
PURPOSE The recently defined visual Strehl ratio that is based on the optical transfer function (VSOTF) has a number of previously unidentified limitations in its calculation that need to be addressed. METHOD The VSOTF is complex, not bounded between zero and one, and can be negative. It is also very sensitive to the presence of prisms in the wavefront(More)
Recent advances in single-cell techniques have provided the opportunity to finely dissect cellular heterogeneity within populations previously defined by “bulk” assays and to uncover rare cell types. In human hematopoiesis, megakaryocytes and erythroid cells differentiate from a shared precursor, the megakaryocyte-erythroid progenitor (MEP), which remains(More)
PURPOSE To compare the repeatability within anterior corneal topography measurements and agreement between measurements with the Pentacam HR rotating Scheimpflug camera and with a previously validated Placido disk-based videokeratoscope (Medmont E300). SETTING Contact Lens and Visual Optics Laboratory, School of Optometry, Queensland University of(More)
We consider analytical modeling of the anterior corneal surface with a set of orthogonal basis functions that are a product of radial polynomials and angular functions. Several candidate basis functions were chosen from the repertoire of functions that are orthogonal in the unit circle and invariant in form with respect to rotation about the origin. In(More)
There are several noninvasive techniques for assessing the kinetics of tear film, but no comparative studies have been conducted to evaluate their efficacies. Our aim is to test and compare techniques based on high-speed videokeratoscopy (HSV), dynamic wavefront sensing (DWS), and lateral shearing interferometry (LSI). Algorithms are developed to estimate(More)
PURPOSE To study the naturally occurring kinetic characteristics of corneal surface. METHODS The right eyes of three subjects (young, early presbyope, and presbyope) were examined. Cardiac signal and longitudinal corneal apex movements were simultaneously measured with electrocardiography (ECG) and a high-speed videokeratoscope, respectively. Time,(More)
Analysis was undertaken of the retinal image characteristics of the best-spectacle corrected eyes of progressing myopes (n = 20, mean age = 22 years; mean spherical equivalent = -3.84 D) and a control group of emmetropes (n = 20, mean age = 23 years; mean spherical equivalent = 0.00 D) before and after a 2h reading task. Retinal image quality was calculated(More)