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Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans.
Progressive rod-cone degeneration (prcd) is a late-onset, autosomal recessive photoreceptor degeneration of dogs and a homolog for some forms of human retinitis pigmentosa (RP). Previously, the… Expand
A protein engineering study of the role of aspartate 158 in the catalytic mechanism of papain.
The controversy concerning the various suggested roles for the side chain of Asp158 in the active site of papain has been clarified by using site-directed mutagenesis. Both wild-type papain and an… Expand
Charge is the major discriminating factor for glutathione reductase versus trypanothione reductase inhibitors.
- C. Faerman, S. Savvides, +6 authors P. Karplus
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 August 1996
Benson et al. (Biochem. J. 1992, 286, 9) reported three novel competitive inhibitors of trypanothione reductase (TR), which were selected to complement a hydrophobic region identified on the TR… Expand
Evidence for the interaction of valine-10 in cystatin C with the S2 subsite of cathepsin B.
- P. Lindahl, D. Ripoll, M. Abrahamson, J. Mort, A. C. Storer
- Chemistry, Medicine
- 12 April 1994
The interactions between wild-type or mutant recombinant forms of human cystatin C and rat cathepsin B were characterized by measuring progress curves for substrate hydrolysis in the presence of… Expand
Immunomodulatory effect of Achyrocline satureioides (LAM.) D.C. aqueous extracts
- A. L. Santos, D. Ripoll, N. Nardi, V. L. Bassani
- Biology, Medicine
- Phytotherapy research : PTR
- 1 February 1999
The immunomodulatory activity of aqueous extract from Achyrocline satureioides, prepared using heating, was investigated with a mitogen‐induced cell proliferation assay and IL‐2 secretion in BALB/c… Expand
P63 Modified Atmosphere Package for 'Bravo de Esmolfe' Apple
Bravo de Esmolfe' is a national apple variety which unique organoleptic characteristics make it a produce of excellency among consumers and its price may reach high values. The aim of this work was… Expand