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Cell cycle-dependent phosphorylation of simian virus 40 (SV40) large tumor antigen (T-ag) on threonine 124 is essential for the initiation of viral DNA replication. A T-ag molecule containing a Thr-->Ala substitution at this position (T124A) was previously shown to bind to the SV40 core origin but to be defective in DNA unwinding and initiation of DNA(More)
Using subfragments of the simian virus 40 (SV40) core origin, we demonstrate that two alternative modules exist for the assembly of T-antigen (T-ag) double hexamers. Pentanucleotides 1 and 3 and the early palindrome (EP) constitute one assembly unit, while pentanucleotides 2 and 4 and the AT-rich region constitute a second, relatively weak, assembly unit.(More)
An automated procedure for estimation of blood cholinesterase activities was evaluated and used to determine baseline cholinesterase activities in rabbits. In addition, the kinetics of cholinesterase inhibition and recovery from diazinon challenge were determined by use of this procedure. The procedure developed is a modification of the colorimetric Ellman(More)
When heavy, highly charged ions (HCI) collide with target gases at low kinetic energies, target electrons are captured into high-lying atomic orbits [1]. The decay of these states can be carefully observed by means of x-ray spectroscopy [2], and compared to recent calculations. Already for light HCI, deviations between theory and experiment have been found,(More)
Bremsstrahlung is one of the basic photon-matter processes occuring in collisions of electrons with atoms and ions. Ion-atom collisions in ion storage rings provide an unique tool to study this process under single-collision conditions in the domain of strong, unpertubated Coulomb fields, such as it prevails in few-electron, high-Z projectiles. Of special(More)
D.B. Thorn1, A. Gumberidze1, S. Trotsenko2,3, D. Banaś4, H. Beyer2,3, W. Chen2, R.D. DuBois1, S. Geyer2,5, R. Grisenti∗2,5, S. Hagmann2, M. Hegewald2,5, S. Hess2,5, C. Kozhuharov2, R. Märtin2,6, I. Orban7, N. Petridis2,5, R. Reuschl8, A. Simon9, U. Spillmann2, A. Surzhykov†2,6, M. Trassinelli8, G. Weber2,6, D.F.A. Winters2,6, N. Winters2,6, D. Yu10, and Th.(More)
Z. Andjelkovic1, Ch. Geppert1,2, J. Krämer1, W. Nörtershäuser1,2, M. Vogel2, V. Hannen3, Ch. Weinheimer3, D.F.A. Winters3, D. Church4, D. Schneider5, S. Bharadia6, D. M. Segal6, R. Thompson6, and the HITRAP collaboration2 1Institut für Kernchemie, Johannes Gutenberg-Universität, Mainz, Germany; 2Gesellschaft für Schwerionenforschung, Darmstadt, Germany;(More)
Heavy highly-charged ions (HCI) are the simplest fewbody systems and the strongest laboratory sources of electromagnetic fields. The new storage rings and synchrotrons that will be built for the future Facility for Antiproton and Ion Research (FAIR) in Darmstadt, will offer unique possibilities to study the structure of such HCI, and the dynamics of their(More)
In a series of experiments involving approximately 500 animals, burned rats were administered the F(ab')2 fragment of antidonor IgG to study the survival of incompatible skin allografts. No prolongation was noted when treatment consisted of antidonor F(ab')2 fragment alone. This was true whether the fragment was raised against donor spleen cells of donor(More)
N. Winckler, K. Beckert, P. Beller, F. Bosch, D. Boutin, C. Brandau, L. Chen, C. Dimopoulou, H.G. Essel, B. Fabian, T. Faestermann, A. Fragner, H. Geissel, I. Hachiuma, E. Haettner, M. Hausmann, S. Hess, T. Izumikawa, P. Kienle, R. Knöbel, C. Kozhuharov, J. Kurcewicz, N. Kuzminchuk, S.A. Litvinov, Yu.A. Litvinov, L. Maier, R. Mao, R. Märtin, M. Mazzocco, F.(More)