D R Storms

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The type I adenylyl cyclase is directly stimulated by Ca2+ and calmodulin in vitro, and the enzyme is also stimulated by increases in intracellular Ca2+ in vivo. Ca2+ stimulation of the enzyme in vivo may be due to direct interactions of the enzyme with Ca2+ and calmodulin or to an indirect mechanism involving stimulation of the enzyme by Ca(2+)-activated(More)
The technique used previously to observe complex formation between bacitracin, Mg++, and Ca5-isoprenyl pyrophosphate has been employed to measure association constants. The constant for the bacitracin A, Mg++, C55-isoprenyl pyrophosphate complex was lo6 M-I. The binding constants for other bacitracin peptides were lower and correlated with their antibiotic(More)
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