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BACKGROUND The ratio of digit lengths is fixed in utero, and may be a proxy indicator for prenatal testosterone levels. METHODS We analysed the right-hand pattern and prostate cancer risk in 1524 prostate cancer cases and 3044 population-based controls. RESULTS Compared with index finger shorter than ring finger (low 2D : 4D), men with index finger(More)
BACKGROUND Arrhythmias are a common cause of morbidity after cardiac surgery. This study assessed the efficacy of prophylactic amiodarone in reducing the incidence of atrial fibrillation or flutter and ventricular arrhythmias after coronary artery surgery. METHODS A double blind, randomised, placebo controlled trial. 60 patients received a 24 hour(More)
BACKGROUND Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wide association studies implicate RAD51B(More)
Sir, We thank Cheema and Sharif (2011) for their interest in our paper. We agree that the strength of our study lies in its size, and therefore, we have been able to make reliable estimates of the association between digit ratio and prostate cancer risk. Epidemiological studies are able to estimate such relationships, but they are more limited in their(More)
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