D. R. Egan

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We report a novel method to accurately evaluate the impact of stretcher gratings on the contrast pedestal of high power laser pulses by precise quantitative characterization of the grating surface. The results are in a good agreement with the experimental measurement. We have, for the first time, established a relation between the contrast pedestal and(More)
Aluminiumeair cells are high-energy density (<400 W h kg 1) primary batteries developed in the 1960s. This review shows the influence of the materials, including: aluminium alloy, oxygen reduction catalyst and electrolyte type, in the battery performance. Two issues are considered: (a) the parasitic corrosion of aluminium at open-circuit potential and under(More)
Optimization of a 5-oxopyrrolopyridine series based upon structure-activity relationships (SARs) developed from our previous efforts on a number of related bicyclic series yielded compound 2s (BMS-767778) with an overall activity, selectivity, efficacy, PK, and developability profile suitable for progression into the clinic. SAR in the series and(More)
Design, synthesis, and SAR of 7-oxopyrrolopyridine-derived DPP4 inhibitors are described. The preferred stereochemistry of these atropisomeric biaryl analogs has been identified as Sa. Compound (+)-3t, with a K(i) against DPP4, DPP8, and DPP9 of 0.37 nM, 2.2, and 5.7 μM, respectively, showed a significant improvement in insulin response after single doses(More)
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