We report the genetic, clinical, electrophysiological, and imaging studies in a family with bilateral striopallidodentate calcinosis (Fahr's disease). The intracerebral calcium deposits occurred before onset of the symptoms in the third decade of life. Progressive neurological deterioration occurred in the fifth decade of life in the proband. Cerebrospinal… (More)
Weight-loss interventions generally improve lipid profiles and reduce cardiovascular disease risk, but effects are variable and may depend on genetic factors. We performed a genetic association analysis of data from 2,993 participants in the Diabetes Prevention Program to test the hypotheses that a genetic risk score (GRS) based on deleterious alleles at 32… (More)
We establish the existence of positive solutions to twin timescale problems given by the dynamic equation −u ∆∇ (t) = ηa(t)f (u(t)), t ∈ (t 1 , t n) ⊂ T with boundary conditions u(t 1) = n−1 i=2 α i u(t i), u ∆ (t n) = 0, or u ∆ (t 1) = 0, u(t n) = n−1 i=2 α i u(t i), using a functional-type cone expansion-compression fixed point theorem.
Coronary heart disease (CHD) is the leading cause of mortality in both developed and developing countries worldwide. Genome-wide association studies (GWAS) have now identified 46 independent susceptibility loci for CHD, however, the biological and disease-relevant mechanisms for these associations remain elusive. The large-scale meta-analysis of GWAS… (More)
In this article we gain solvability to a nonlinear, second-order difference equation with discrete Neumann boundary conditions. Our methods involve new inequalities on the right-hand side of the difference equation and Schaefer's theorem in the finite-dimensional space setting.
—Existence criteria for two positive solutions to a nonlinear, even-order stacked delta-nabla boundary value problem with stacked, vanishing conditions at the two endpoints are found using the method of Green's functions. A few examples are given for standard time scales. The corresponding even-order nabla-delta problem is also discussed in detail.