D. P. Sanderson

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Crohn's disease has long been suspected of having a mycobacterial cause. Mycobacterium paratuberculosis is a known cause of chronic enteritis in animals, including primates, but may be very difficult to detect by culture. IS900 is a multicopy genomic DNA insertion element highly specific forM paratuberculosis. A polymerase chain reaction (PCR) based on the(More)
AIMS To determine the cost-effectiveness of a structured treatment and teaching programme (STTP) combining dietary freedom with insulin adjustment for Type 1 diabetes. METHODS Incremental cost-effectiveness analysis based on effectiveness data from three RCTs in Germany, Austria, and Dose Adjustment for Normal Eating (DAFNE) in the UK, to model the(More)
Recent research has shown that electrical stimulation is effective in treatment programs designed to maintain or gain range of motion, to facilitate voluntary motor control, and to strengthen muscles weakened by disuse. All of these treatment goals are relevant to the head-injured patient who frequently demonstrates profound disuse atrophy, joint(More)
BACKGROUND Intermediate care (IC) services have been widely introduced in England and have the strategic objectives of reducing hospital and long-term care use. There is uncertainty about the clinical outcomes of these services and whether their strategic aims will be realised. SETTING A metropolitan city in northern England. DESIGN A quasi-experimental(More)
This paper describes the first part of a two-stage research project designed to investigate the clinical and service outcomes of a comprehensive intermediate care service. It is a baseline study of patients presenting to two elderly care departments as emergencies with the clinical syndromes of falls, incontinence, confusion or poor mobility before the(More)
This paper describes recent reforms of quality assurance (QA) for the education of nurses, midwives and health visitors and reports qualitative findings from a study of how they are working out in practice. This study reported whether the stakeholders consider the system to be adequate for the principal aim of public protection. Using a postal survey and(More)
BACKGROUND Learning disability (LD) is a serious and lifelong condition characterised by the impairment of cognitive and adaptive skills. Some cases of LD with unidentified causes may be linked to genetic factors. Next-generation sequencing (NGS) techniques are new approaches to genetic testing that are expected to increase diagnostic yield. OBJECTIVES(More)
The Hierarchical Simulation Language (HSL) was designed and developed to serve process-oriented simulation of discrete systems. It is interpreter-based and hence offers certain advantages, such as portability (hexdware independence) and modifiability (during program execution). An HSL model consists of two major sections. The Environment contains the(More)