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Soluble fractions of chick embryonic skeletal muscle stimulated radial outgrowth of long neurites from peripheral ganglia. Dorsal root ganglia were more responsive to the growth stimulus of muscle fractions than sympathetic ganglia. Muscle fractions from chicks immobilized with d-tubocurarine chloride (dtc) were significantly more effective in stimulating(More)
The addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to defined growth medium stimulated an in tense neurite outgrowth from chick sensory ganglia expiants. The development of radial neuntes was concentration depend ent. At low concentrations of TPA (1.6 to 16 nw), neuntes were long but moderate in numbers. At higher concentrations(More)
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