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The addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to defined growth medium stimulated an intense neurite outgrowth from chick sensory ganglia explants. The development of radial neurites was concentration dependent. At low concentrations of TPA (1.6 to 16 nM), neurites were long but moderate in numbers. At higher concentrations(More)
Soluble fractions of chick embryonic skeletal muscle stimulated radial outgrowth of long neurites from peripheral ganglia. Dorsal root ganglia were more responsive to the growth stimulus of muscle fractions than sympathetic ganglia. Muscle fractions from chicks immobilized with d-tubocurarine chloride (dtc) were significantly more effective in stimulating(More)
The addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to defined growth medium stimulated an in tense neurite outgrowth from chick sensory ganglia expiants. The development of radial neuntes was concentration depend ent. At low concentrations of TPA (1.6 to 16 nw), neuntes were long but moderate in numbers. At higher concentrations(More)
Soluble fractions of homogenized skeletal muscle were found to promote neuronal migration and neuritic and glial outgrowth from embryonic chick spinal cord explants. Fractions obtained from skeletal muscle immobilized by prolonged treatment with curare were significantly more effective than normal muscle in accelerating neuronal and glial development.(More)
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