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MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness. miR-9-mediated E-cadherin downregulation results in the activation of(More)
Gene expression analysis of microRNA molecules is becoming increasingly important. In this study we assess the use of the mean expression value of all expressed microRNAs in a given sample as a normalization factor for microRNA real-time quantitative PCR data and compare its performance to the currently adopted approach. We demonstrate that the mean(More)
BACKGROUND Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy neuroblastomas, elevated MYCN mRNA and protein levels are paradoxically associated with a more favorable clinical phenotype, including disseminated tumors that(More)
High incidence of chemotherapy resistance is the primary cause of treatment failure in a subset of neuroblastomas with amplified MYCN. We have reported previously that ectopic MYCN expression promotes proliferation of neuroblastoma Tet21N cells and simultaneously sensitizes them to the drug-induced apoptosis. In search for genes that are involved in(More)
PURPOSE This study was performed to evaluate the structure-function relationship between Bruch's membrane opening (BMO) parameters of the optic nerve head (ONH) and visual field (VF) sensitivity. METHODS Forty-six right eyes of 46 patients with open-angle glaucoma (OAG) in the patient group and 12 right eyes in the control group were included. Standard(More)
Chapter One Figure 1.1: Wilkinson tract in relation to the state of Michigan. 1.2 Figure 1.2: Digital orthophoto showing location of Wilkinson Tract in Baraga. 1.3 Figure 1.3: A view of the scrub/shrub swamp on the Wilkinson tract. 1.4 Figure 1.4: Photo of one of several mineral marshes present. 1.4 Figure 1.5: A conifer swamp located on Wilkinson tract.(More)
and Boolean factor analysis. The availability of new programs is announced to all who have ordered copies of the BMDP programs previously and in BMD Communications. Programs are not released out of house to anyone before official release to everyone. The content of programs is under the direction of a committee of statisticians and computer scientists who(More)
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