D. Morley

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We have implemented five drug-like filters, based on 1D and 2D molecular descriptors, and applied them to characterize the drug-like properties of commercially available chemical compounds. In addition to previously published filters (Lipinski and Veber), we implemented a filter for medicinal chemistry tractability based on lists of chemical features drawn(More)
BACKGROUND Zoonotic visceral leishmaniasis is endemic in the Mediterranean Basin, where the dog is the main reservoir host. The disease's causative agent, Leishmania infantum, is transmitted by blood-feeding female sandflies. This paper reports an integrative study of canine leishmaniasis in a region of France spanning the southwest Massif Central and the(More)
As the development of movement skills are so crucial to a child's involvement in lifelong physical activity and sport, the purpose of this study was to assess the motor proficiency of children aged 4-7 years (range=4.3-7.2 years), whilst considering gender and socioeconomic status. 369 children (176 females, 193 males, aged=5.96 ± 0.57 years) were assessed(More)
Prediction of adult performance from early age talent identification in sport remains difficult. Talent identification research has generally been performed using univariate analysis, which ignores multivariate relationships. To address this issue, this study used a novel higher-dimensional model to orthogonalize multivariate anthropometric and fitness data(More)
Problem reduction is a basic concept behind much of AI search. The standard approach is to view problem reduction in terms of AND/OR graphs and then to concentrate on graph search techniques to nd a solution to the original problem. However these techniques depend upon global graph properties. By taking a more object-oriented approach we can ignore the(More)
Material in this publication may be copied without restraint for library, abstract service, educational, or personal research purposes; however, this source should be appropriately acknowledged. Distribution: Electronic copies of this series may be obtained from the Integrated Ocean Drilling Program (IODP) Publication Services homepage on the World Wide Web(More)
This report was prepared from shipboard files by scientists who participated in the cruise. The report was assembled under time constraints and does not contain all works and findings that will appear in the DISCLAIMER Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily(More)
  • Australia Canada, Chinese, Taipei Korea, S Hipboard, S Cientific, P Arty +59 others
  • 1998
This report was prepared from shipboard files by scientists who participated in the cruise. The report was assembled under time constraints and does not contain all works and findings that will appear in the DISCLAIMER Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily(More)
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