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Alzheimer's disease (AD) is a devastating neurological disorder characterized by loss of cognitive skills and progressive dementia. The pathological hallmark of AD is the presence of numerous senile plaques throughout the hippocampus and cerebral cortex associated with degenerating axons, neurofibrillary tangles, and gliosis. The core of the senile plaque(More)
The senile plaques of Alzheimer's disease are foci of local inflammatory responses, as evidenced by the presence of acute phase proteins and oxidative damage. Fibrillar forms of beta-amyloid (Abeta), which are the primary constituents of senile plaques, have been shown to activate tyrosine kinase-dependent signal transduction cascades, resulting in(More)
OBJECTIVE To determine the efficacy of intranasal aqueous triamcinolone acetonide in treating the tympanometric signs and symptoms of eustachian tube dysfunction, such as otitis media with effusion and negative middle ear pressure. DESIGN Randomized, placebo-controlled, double-blind prospective clinical trial. SETTING Tertiary referral clinic. (More)
It has been claimed that gentamicin assays on the serum of jaundiced patients give falsely low levels and suggested that the antibiotic in such sera is bound to bile acids and thus is partly inactivated. No evidence of such inactivation has been obtained (i) in the serum of jaundiced patients treated with gentamicin, (ii) in sera with high bilirubin(More)
A self-training visual inspection system using a connectionist classifier is presented. The system is composed of a control unit, a signal-processing unit, and a connectionist classifier. The control unit both generates the training set and performs the function of teacher to the classifier. The second unit compresses the two-dimensional image into a(More)